Regulation of CDH1 Expression and Function

Zhang N, Häring M, Wolf F, Großhans J, Kong D. Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis. Mar Life Sci Technol. 2023 Nov 24;5(4):585–601. doi: 10.1007/s42995-023-00206-w.; Loh CY, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK, Chong PP, Looi CY. The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells. 2019 Sep 20;8(10). PMID: 31547193; PMCID: PMC6830116.; Bruner HC, Derksen PWB. Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer. Cold Spring Harb Perspect Biol. 2017 May 15;10(3):a029330. doi: 10.1101/cshperspect.a029330.; Li G, Pan T, Guo D, Li L. Regulatory Variants and Disease: The E-Cadherin -160C/A SNP as an Example. Molecular Biology International. 2014 Sep 02;2014():1–9. doi: 10.1155/2014/967565.; Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R. The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC. European Journal of Human Genetics. 2012 Aug 01;21(3):301–9. doi: 10.1038/ejhg.2012.159.; Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN. Multifactorial regulation of E-cadherin expression: an integrative study. Mol Cancer Ther. 2010 Jan;9(1):1–16. PMID: 20053763; PMCID: PMC2821037.; Janda E, Nevolo M, Lehmann K, Downward J, Beug H, Grieco M. Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene. 2006 Nov 16;25(54):7117–30. doi: 10.1038/sj.onc.1209701. PMID: 16751808.; Gumbiner BM. Regulation of cadherin adhesive activity. J Cell Biol. 2000 Feb 07;148(3):399–404. PMID: 10662767; PMCID: PMC2174801.

Metabolites

beta-D-Glucose

Formula: C6H12O6 (180.0633852)

CAS ID: 492-61-5

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.1.-
2.1.1.361 [histone H4]-lysine20 N-methyltransferase S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase
2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase dolichyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligopolysaccharidotransferase
3.4.21.89 Signal peptidase I
3.5.1.98 histone deacetylase histone amidohydrolase


Proteins

Protein ID name full name