Lanosterol biosynthesis
Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife. 2015 Jun 26;4():e07999. PMID: 26114596; PMCID: PMC4501332.; Faust PL, Kovacs WJ. Cholesterol biosynthesis and ER stress in peroxisome deficiency. Biochimie. 2014 Mar;98():75–85. doi: 10.1016/j.biochi.2013.10.019. PMID: 24211592.; Hogenboom S, Romeijn GJ, Houten SM, Baes M, Wanders RJA, Waterham HR. Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. Journal of Lipid Research. 2002 Jan;43(1):90–8. doi: 10.1016/s0022-2275(20)30191-7.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.5.1.- | |||
| 1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) | (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating) | |
| 2.5.1.1 | dimethylallyltranstransferase | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate prenyltranstransferase | |
| 2.5.1.10 | (2E,6E)-farnesyl diphosphate synthase | geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase | |
| 2.5.1.29 | geranylgeranyl diphosphate synthase | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase | |
| 2.7.1.36 | mevalonate kinase | ATP:(R)-mevalonate 5-phosphotransferase | |
| 3.6.1.68 | geranyl diphosphate phosphohydrolase | geranyl-diphosphate phosphohydrolase | |
| 4.1.1.33 | diphosphomevalonate decarboxylase | ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming) |
Proteins
| Protein ID | name | full name |
|---|