inosine-5'-phosphate biosynthesis I

Zhang Y, Morar M, Ealick SE. Structural biology of the purine biosynthetic pathway. Cellular and Molecular Life Sciences. 2008 Aug 19;65(23):3699–724. doi: 10.1007/s00018-008-8295-8.; Meyer E, Kappock TJ, Osuji C, Stubbe J. Evidence for the Direct Transfer of the Carboxylate of N5-Carboxyaminoimidazole Ribonucleotide (N5-CAIR) To Generate 4-Carboxy-5-aminoimidazole Ribonucleotide Catalyzed by Escherichia coli PurE, an N5-CAIR Mutase. Biochemistry. 1999 Feb 18;38(10):3012–8. doi: 10.1021/bi9827159.; Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J. N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. Biochemistry. 1994 Mar 01;33(8):2269–78. doi: 10.1021/bi00174a038. PMID: 8117684.; He B, Smith JM, Zalkin H. Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. J Bacteriol. 1992 Jan;174(1):130–6. doi: 10.1128/jb.174.1.130-136.1992.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

maleate(2-)

Formula: C4H2O4 (113.99530920000001)

CAS ID: 142-44-9

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

Formula: C9H13N4O8P (336.0470988)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase
3.5.4.10 IMP cyclohydrolase IMP 1,2-hydrolase (decyclizing)
4.3.2.2 adenylosuccinate lyase N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
5.4.99.18 5-(carboxyamino)imidazole ribonucleotide mutase 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name
P09029 purK N5-carboxyaminoimidazole ribonucleotide synthase
P0A7D7 purC Phosphoribosylaminoimidazole-succinocarboxamide synthase
P0AB89 purB Adenylosuccinate lyase
P0AG18 purE N5-carboxyaminoimidazole ribonucleotide mutase
P15639 purH Bifunctional purine biosynthesis protein PurH