Ribavirin ADME

Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

1H-1,2,4-Triazole-3-carboxamide

Formula: C3H4N4O (112.0385094)

CAS ID: 3641-08-5

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.7.1.20 adenosine kinase ATP:adenosine 5'-phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
3.6.1.66 XTP/dITP diphosphatase XTP/dITP diphosphohydrolase (diphosphate-forming)


Proteins

Protein ID name full name
P36010 YNK1 Nucleoside diphosphate kinase
P47119 HAM1 Inosine triphosphate pyrophosphatase
P47143 ADO1 Adenosine kinase
Q05788 PNP1 Purine nucleoside phosphorylase