Ribavirin ADME

Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

1H-1,2,4-Triazole-3-carboxamide

Formula: C3H4N4O (112.0385094)

CAS ID: 3641-08-5

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.7.1.20 adenosine kinase ATP:adenosine 5'-phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
3.6.1.66 XTP/dITP diphosphatase XTP/dITP diphosphohydrolase (diphosphate-forming)


Proteins

Protein ID name full name
P49740 ndk1 Nucleoside diphosphate kinase
P78825 ado1 Adenosine kinase
Q9UTG1 PNPH_SCHPO Putative purine nucleoside phosphorylase
Q9UU89 ITPA_SCHPO Inosine triphosphate pyrophosphatase