Glutamate and glutamine metabolism
Häussinger D. Liver glutamine metabolism. JPEN J Parenter Enteral Nutr. 1990 Jul;14(4 Suppl):56S–62S. doi: 10.1177/014860719001400405. PMID: 2205732.; Owen OE, Reichard GA, Patel MS, Boden G. Energy metabolism in feasting and fasting. Adv Exp Med Biol. 1979;111():169–88. doi: 10.1007/978-1-4757-0734-2_8. PMID: 371355.; Felig P. Amino acid metabolism in man. Annu Rev Biochem. 1975;44():933–55. doi: 10.1146/annurev.bi.44.070175.004441. PMID: 1094924.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.2.1.41 | glutamate-5-semialdehyde dehydrogenase | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | |
| 1.5.1.2 | pyrroline-5-carboxylate reductase | L-proline:NAD(P)+ 5-oxidoreductase | |
| 2.6.1.1 | aspartate transaminase | L-aspartate:2-oxoglutarate aminotransferase | |
| 2.6.1.13 | ornithine aminotransferase | L-ornithine:2-oxo-acid aminotransferase | |
| 2.6.1.7 | kynurenine-oxoglutarate transaminase | L-kynurenine:2-oxoglutarate aminotransferase | |
| 6.3.1.2 | glutamine synthetase | L-glutamate:ammonia ligase (ADP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P07991 | CAR2 | Ornithine aminotransferase |
| P32263 | PRO3 | Pyrroline-5-carboxylate reductase |
| P32288 | GLN1 | Glutamine synthetase |
| P47039 | BNA3 | Probable kynurenine--oxoglutarate transaminase BNA3 |
| P54885 | PRO2 | Gamma-glutamyl phosphate reductase |
| Q01802 | AAT1 | Aspartate aminotransferase, mitochondrial |