beta-D-Fructose 2,6-bisphosphate (BioCAD00000007279)

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Metabolite Card

Formula: C6H14O12P2 (339.9961)
SMILES: OC[C@@]1(OP(O)(O)=O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O

Synonyms [en]

D-Fructose 2,6-bisphosphate; beta-D-fructose 2,6-bisphosphate; Fructose 2,6-diphosphate; 2,6-Di-O-phosphono-beta-D-fructofuranose; Phosphofructokinase activator; Phosphofructokinase activation factor

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

beta-D-Fructose 2,6-bisphosphate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000007279). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

D-Fructose 2,6-bisphosphate (CAS: 77164-51-3), also known as phosphofructokinase activator, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. D-Fructose 2,6-bisphosphate is a regulatory molecule controlling the activity of the enzyme phosphofructokinase-1 or PFK1 (in mammals). PFK1, in turn, is the key regulatory enzyme in the central metabolic pathway glycolysis. D-Fructose 2,6-bisphosphate has the effect of increasing the activity of PFK1, thus increasing the rate at which the principle food molecule glucose is broken down. At the same time, this regulatory molecule also inhibits the opposing enzyme (FBPase1) in the reverse pathway (gluconeogenesis) so that the synthesis of glucose is not taking place in the same cell where glucose is being broken down (which would be wasteful).

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 79082-92-1
  • PubChem: 105021
  • ChEBI: ChEBI:28602
  • HMDB: HMDB0001047
  • HMDB: HMDB01047
  • KEGG: C00665
  • NCBI MeSH: fructose 2,6-diphosphate
  • Wikipedia: Fructose_2,6-bisphosphate
  • Wikipedia: Fructose_2\,6-bisphosphate
  • RefMet: RM0155902
  • MoNA: HMDB0001047_c_ms_99645
  • MoNA: HMDB0001047_c_ms_99646
  • MoNA: KO000759
  • MoNA: KO000760
  • MoNA: KO000761
  • MoNA: KO000762
  • MoNA: KO000763
  • Metlin: METLIN_5964
  • Coconut NaturalProduct: CNP0251455.1
  • Coconut NaturalProduct: CNP0251455.3
  • Coconut NaturalProduct: CNP0452698.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00763 3.1.3.46 beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase
KEGG:R02730 3.1.3.54 D-fructose-2,6-bisphosphate 6-phosphohydrolase
KEGG:R02731 3.1.3.46 D-fructose-2,6-bisphosphate 2-phosphohydrolase
KEGG:R02732 2.7.1.105 ATP:D-fructose-6-phosphate 2-phosphotransferase
KEGG:R13202 2.7.1.105 ATP:D-fructose-6-phosphate 2-phosphotransferase
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP3915 Angiopoietin-like protein 8 regulatory pathway
WikiPathways:WP3602 Metabolism overview
PathBank:SMP0120625 Fructosuria
PathBank:SMP0000064 Fructose and Mannose Degradation
PathBank:SMP0087197 Fructose and Mannose Degradation
PathBank:SMP0012445 Fructose Metabolism
PathBank:SMP0120657 Fructose Intolerance, Hereditary
PathBank:SMP0000725 Fructose Intolerance, Hereditary
PathBank:SMP0120844 Fructosuria
PathBank:SMP0120876 Fructose Intolerance, Hereditary
PathBank:SMP0000561 Fructosuria
PathBank:SMP0002314 Fructose Metabolism
PathBank:SMP0087296 Fructose and Mannose Degradation
PathBank:SMP0063614 Fructose and Mannose Degradation
View All Pathways