Gemcitabine Metabolism Pathway

Metabolites

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

Gemcitabine

Formula: C9H11F2N3O4 (263.071759)

CAS ID: 95058-81-4

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Etoposide glucuronide

Formula: C35H40O19 (764.216369)

CAS ID: 100007-55-4

Gemcitabine diphosphate

Formula: C9H13F2N3O10P2 (423.00442419999996)

CAS ID:

Gemcitabine monophosphate

Formula: C9H12F2N3O7P (343.0380916)

CAS ID: 116371-67-6



Enzyme

EC Number name full name note
3.1.11.-
1.17.4.1 ribonucleoside-diphosphate reductase 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
2.1.1.45 thymidylate synthase 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
2.7.1.113 deoxyguanosine kinase ATP:deoxyguanosine 5'-phosphotransferase
2.7.1.74 deoxycytidine kinase NTP:deoxycytidine 5'-phosphotransferase
2.7.1.76 2'-deoxyadenosine kinase ATP:2'-deoxyadenosine 5'-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.13.3 histidine kinase ATP:protein-L-histidine N-phosphotransferase
2.7.4.14 UMP/CMP kinase ATP:CMP(UMP) phosphotransferase
2.7.4.18 farnesyl-diphosphate kinase ATP:farnesyl-diphosphate phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
3.5.4.12 dCMP deaminase dCMP aminohydrolase
6.3.4.2 CTP synthase (glutamine hydrolysing) UTP:ammonia ligase (ADP-forming)


Proteins

Protein ID name full name