Succinyl-CoA
Succinyl-CoA is an important intermediate in the citric acid cycle, where it is synthesized from α-Ketoglutarate by α-ketoglutarate dehydrogenase (EC 1.2.4.2) through decarboxylation, and is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (EC 6.2.1.5). Succinyl-CoA may be an end product of peroxisomal beta-oxidation of dicarboxylic fatty acids; the identification of an apparently specific succinyl-CoA thioesterase (ACOT4, EC 3.1.2.3, hydrolyzes succinyl-CoA) in peroxisomes strongly suggests that succinyl-CoA is formed in peroxisomes. Acyl-CoA thioesterases (ACOTs) are a family of enzymes that catalyze the hydrolysis of the CoA esters of various lipids to the free acids and coenzyme A, thereby regulating levels of these compounds. (PMID: 16141203).
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00265 | 1.2.1.52 | 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating) |
| KEGG:R00405 | 6.2.1.5 | succinate:CoA ligase (ADP-forming) |
| KEGG:R00406 | 2.8.3.22 | succinyl-CoA:(S)-malate CoA-transferase |
| KEGG:R00407 | 3.1.2.3 | succinyl-CoA hydrolase |
| KEGG:R00410 | 2.8.3.5 | succinyl-CoA:acetoacetate CoA-transferase |
| KEGG:R00432 | 6.2.1.4 | succinate:CoA ligase (GDP-forming) |
| KEGG:R00727 | 6.2.1.4 | succinate:CoA ligase (IDP-forming) |
| KEGG:R00829 | 2.3.1.16 | succinyl-CoA:acetyl-CoA C-acyltransferase; |
| KEGG:R00830 | 2.3.1.37 | succinyl-CoA:glycine C-succinyltransferase (decarboxylating) |
| KEGG:R00832 | 2.3.1.109 | succinyl-CoA:L-arginine N2-succinyltransferase |
| KEGG:R00833 | 5.4.99.2 | (R)-methylmalonyl-CoA CoA-carbonylmutase |
| KEGG:R01197 | 1.2.7.3 | 2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating) |
| KEGG:R01559 | 2.8.3.2 | succinyl-CoA:oxalate CoA-transferase |
| KEGG:R01777 | 2.3.1.46 | succinyl-CoA:L-homoserine O-succinyltransferase |
| KEGG:R01780 | 2.8.3.5 | succinyl-CoA:3-oxo-acid CoA-transferase |
| KEGG:R02084 | 2.8.3.13 | succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase |
| KEGG:R02407 | 2.8.3.- | succinyl-CoA:itaconate CoA-transferase |
| KEGG:R02570 | 2.3.1.61 | succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase |
| KEGG:R02990 | 2.8.3.6 | succinyl-CoA:3-oxoadipate CoA-transferase |
| KEGG:R03154 | 2.8.3.22 | succinyl-CoA:(S)-citramalate CoA-transferase |
| KEGG:R04365 | 2.3.1.117 | succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase |
| KEGG:R05587 | 2.3.1.310 | C09820 + C00010<=>C00512 + C00091 |
| KEGG:R05588 | 2.8.3.15 | C09816 + C00091<=>C09817 + C00042 |
| KEGG:R06904 | 2.8.3.- | C14115 + C00091<=>C14116 + C00042 |
| KEGG:R06908 | 2.3.1.- | C14119 + C00010<=>C14120 + C00091 |
| KEGG:R08549 | 1.2.1.105 | 2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); |
| KEGG:R09280 | 1.2.1.76 | succinate-semialdehyde:NADP+ oxidoreductase (CoA-acylating) |
| KEGG:R10343 | 2.8.3.18 | succinyl-CoA:acetate CoA-transferase |
| KEGG:R10640 | 2.8.3.20 | succinyl-CoA:(R)-citramalate CoA-transferase |
| KEGG:R10641 | 2.8.3.20 | succinyl-CoA:(R)-malate CoA-transferase |