Dihydrotestosterone

Dihydrotestosterone is a potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. -- Pubchem; Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. DHT is thought to be approximately 30 times more potent than testosterone because of increased affinity to the androgen receptor.

ID EC Number Name
KEGG:R02497 1.3.1.22 dihydrotestosterone:NADP+ delta4-oxidoreductase
KEGG:R04330 1.1.1.53 androstan-3alpha,17beta-diol:NAD+ oxidoreductase
KEGG:R04344 1.1.1.210 3beta-hydroxysteroid:NADP+ oxidoreductase
KEGG:R08963 1.1.1.50 androstan-3alpha,17beta-diol:NADP+ oxidoreductase
KEGG:R13220 1.1.1.51 dihydrotestosterone:NADP+ 17-oxidoreductase
KEGG:R13221 1.1.1.51 dihydrotestosterone:NAD+ 17-oxidoreductase
Rhea:RHEA:16298 1.1.1.210 5α-androstane-3β,17β-diol + NADP+ => 17β-hydroxy-5α-androstan-3-one + NADPH + H+
Rhea:RHEA:16299 1.1.1.210 17β-hydroxy-5α-androstan-3-one + NADPH + H+ => 5α-androstane-3β,17β-diol + NADP+
Rhea:RHEA:16300 1.1.1.210 5α-androstane-3β,17β-diol + NADP+ <=> 17β-hydroxy-5α-androstan-3-one + NADPH + H+
Rhea:RHEA:41993 17β-hydroxy-5α-androstan-3-one + NAD+ => 5α-androstan-3,17-dione + NADH + H+
Rhea:RHEA:41994 5α-androstan-3,17-dione + NADH + H+ => 17β-hydroxy-5α-androstan-3-one + NAD+
Rhea:RHEA:41995 17β-hydroxy-5α-androstan-3-one + NAD+ <=> 5α-androstan-3,17-dione + NADH + H+
Rhea:RHEA:42005 1.1.1.53 5α-androstane-3α,17β-diol + NAD+ => 17β-hydroxy-5α-androstan-3-one + NADH + H+
Rhea:RHEA:42006 1.1.1.53 17β-hydroxy-5α-androstan-3-one + NADH + H+ => 5α-androstane-3α,17β-diol + NAD+
Rhea:RHEA:42007 1.1.1.53 5α-androstane-3α,17β-diol + NAD+ <=> 17β-hydroxy-5α-androstan-3-one + NADH + H+
Rhea:RHEA:42117 5α-androstane-3α,17β-diol + NADP+ => 17β-hydroxy-5α-androstan-3-one + NADPH + H+
Rhea:RHEA:42118 17β-hydroxy-5α-androstan-3-one + NADPH + H+ => 5α-androstane-3α,17β-diol + NADP+
Rhea:RHEA:42119 5α-androstane-3α,17β-diol + NADP+ <=> 17β-hydroxy-5α-androstan-3-one + NADPH + H+
Rhea:RHEA:42121 17β-hydroxy-5α-androstan-3-one + NADP+ => 5α-androstan-3,17-dione + NADPH + H+
Rhea:RHEA:42122 5α-androstan-3,17-dione + NADPH + H+ => 17β-hydroxy-5α-androstan-3-one + NADP+
Rhea:RHEA:42123 17β-hydroxy-5α-androstan-3-one + NADP+ <=> 5α-androstan-3,17-dione + NADPH + H+
Rhea:RHEA:42185 5α-androstane-3β,17β-diol + NAD+ => 17β-hydroxy-5α-androstan-3-one + NADH + H+
Rhea:RHEA:42186 17β-hydroxy-5α-androstan-3-one + NADH + H+ => 5α-androstane-3β,17β-diol + NAD+
Rhea:RHEA:42187 5α-androstane-3β,17β-diol + NAD+ <=> 17β-hydroxy-5α-androstan-3-one + NADH + H+
Rhea:RHEA:50821 1.3.1.22 17β-hydroxy-5α-androstan-3-one + NADP+ => testosterone + NADPH + H+
Rhea:RHEA:50822 1.3.1.22 testosterone + NADPH + H+ => 17β-hydroxy-5α-androstan-3-one + NADP+
Rhea:RHEA:50823 1.3.1.22 17β-hydroxy-5α-androstan-3-one + NADP+ <=> testosterone + NADPH + H+
Rhea:RHEA:53001 17β-hydroxy-5α-androstan-3-one + UDP-α-D-glucuronate => 5α-dihydrotestosterone 17-O-(β-D-glucuronate) + UDP + H+
Rhea:RHEA:53002 5α-dihydrotestosterone 17-O-(β-D-glucuronate) + UDP + H+ => 17β-hydroxy-5α-androstan-3-one + UDP-α-D-glucuronate
Rhea:RHEA:53003 17β-hydroxy-5α-androstan-3-one + UDP-α-D-glucuronate <=> 5α-dihydrotestosterone 17-O-(β-D-glucuronate) + UDP + H+