KEGG:R07085

CYP1A1, CYP1B1, CYP2C9, CYP3A4

benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

Benzo[a]pyrene-7,8-dihydrodiol[C20H14O2] + NADPH[C21H30N7O17P3] + Oxygen[O2] + H+[H] = Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide[C20H14O3] + NADP+[C21H29N7O17P3] + H2O[H2O]

DB Links

Alias

Metabolites

Substrates
metabolite compartment Structure
Benzo[a]pyrene-7,8-dihydrodiol

Formula: C20H14O2 		Cytoplasm
NADPH

Formula: C21H30N7O17P3 		Cytoplasm
Oxygen

Formula: O2 		Cytoplasm
H+

Formula: H 		Cytoplasm
Products
metabolite compartment Structure
Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide

Formula: C20H14O3		 Cytoplasm
NADP+

Formula: C21H29N7O17P3		 Cytoplasm
H2O

Formula: H2O		 Cytoplasm