Rhea:RHEA:61031

This reaction can occur spontaneously. Itaconate contains an electrophilic alpha,beta-unsaturated carboxylic acid that could potentially alkylate protein cysteine residues by a Michael addition to form a 2,3-dicarboxypropyl adduct [PMID:29590092].

itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]

= Itaconate[C5H6O4] + [] + []

DB Links

  • Rhea: RHEA:61031
Alias

Metabolites

Substrates
metabolite compartment Structure
Products
metabolite compartment Structure
Itaconate

Formula: C5H6O4		 Cytoplasm


Formula: 		Cytoplasm


Formula: 		Cytoplasm