数据之源，洞见之始

L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂

= [] + Formaldehyde[CH2O] + succinate(2-)[C4H4O4] + CO2[CO2] + [] + 2-Oxoglutarate[C5H6O5] + Oxygen[O2]

DB Links

• EC Number: 1.14.11.27
• Rhea: RHEA:42034

Alias

• [Rhea:RHEA:10785] N⁶-methyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂ => L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:10786] L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂ => N⁶-methyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:10787] N⁶-methyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂ <=> L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:21789] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂ => N⁶-methyl-L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:21790] N⁶-methyl-L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:21791] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶-methyl-L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:30300] a methylated nucleobase within DNA + 2-oxoglutarate + O₂ => a nucleobase within DNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:30301] a nucleobase within DNA + formaldehyde + succinate + CO₂ => a methylated nucleobase within DNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:30302] a methylated nucleobase within DNA + 2-oxoglutarate + O₂ <=> a nucleobase within DNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:42033] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂ => L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:42034] L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:42035] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂ <=> L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:49517] an N¹-methyladenosine in mRNA + 2-oxoglutarate + O₂ => an adenosine in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:49518] an adenosine in mRNA + formaldehyde + succinate + CO₂ => an N¹-methyladenosine in mRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:49519] an N¹-methyladenosine in mRNA + 2-oxoglutarate + O₂ <=> an adenosine in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:49521] an N⁶-methyladenosine in mRNA + 2-oxoglutarate + O₂ => an adenosine in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:49522] an adenosine in mRNA + formaldehyde + succinate + CO₂ => an N⁶-methyladenosine in mRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:49523] an N⁶-methyladenosine in mRNA + 2-oxoglutarate + O₂ <=> an adenosine in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:49525] an N⁶-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O₂ => a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:49526] a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO₂ => an N⁶-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:49527] an N⁶-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O₂ <=> a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:54577] an N¹-methyladenosine in tRNA + 2-oxoglutarate + O₂ => an adenosine in tRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:54578] an adenosine in tRNA + formaldehyde + succinate + CO₂ => an N¹-methyladenosine in tRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:54579] an N¹-methyladenosine in tRNA + 2-oxoglutarate + O₂ <=> an adenosine in tRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:57897] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O₂ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:57898] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO₂ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:57899] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O₂ <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:57901] N⁶-methyladenosine in U6 snRNA + 2-oxoglutarate + O₂ => adenosine in U6 snRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:57902] adenosine in U6 snRNA + formaldehyde + succinate + CO₂ => N⁶-methyladenosine in U6 snRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:57903] N⁶-methyladenosine in U6 snRNA + 2-oxoglutarate + O₂ <=> adenosine in U6 snRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:57905] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O₂ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:57906] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO₂ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:57907] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O₂ <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:58349] N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O₂ => L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:58350] L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO₂ => N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:58351] N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O₂ <=> L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:58353] N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O₂ => N^ω-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:58354] N^ω-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO₂ => N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O₂
• [Rhea:RHEA:58355] N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O₂ <=> N^ω-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:58357] N^ω-methyl-L-arginyl-[protein] + 2-oxoglutarate + O₂ => L-arginyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:58358] L-arginyl-[protein] + formaldehyde + succinate + CO₂ => N^ω-methyl-L-arginyl-[protein] + 2-oxoglutarate + O₂
• [Rhea:RHEA:58359] N^ω-methyl-L-arginyl-[protein] + 2-oxoglutarate + O₂ <=> L-arginyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:58469] N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O₂ => L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:58470] L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO₂ => N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:58471] N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O₂ <=> L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:58473] N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O₂ => N^ω-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:58474] N^ω-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO₂ => N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O₂
• [Rhea:RHEA:58475] N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O₂ <=> N^ω-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60189] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2 2-oxoglutarate + 2 O₂ => L-lysyl⁹-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60190] L-lysyl⁹-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:60191] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2 2-oxoglutarate + 2 O₂ <=> L-lysyl⁹-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60193] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂ => N⁶-methyl-L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60194] N⁶-methyl-L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60195] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶-methyl-L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60197] N⁶-methyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂ => L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60198] L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂ => N⁶-methyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60199] N⁶-methyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂ <=> L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60201] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 2 2-oxoglutarate + 2 O₂ => N⁶-methyl-L-lysyl⁹-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60202] N⁶-methyl-L-lysyl⁹-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:60203] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 2 2-oxoglutarate + 2 O₂ <=> N⁶-methyl-L-lysyl⁹-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60205] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂ => N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60206] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60207] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60209] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 3 2-oxoglutarate + 3 O₂ => L-lysyl⁴-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO₂
• [Rhea:RHEA:60210] L-lysyl⁴-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 3 2-oxoglutarate + 3 O₂
• [Rhea:RHEA:60211] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 3 2-oxoglutarate + 3 O₂ <=> L-lysyl⁴-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO₂
• [Rhea:RHEA:60213] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂ => N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60214] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60215] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60217] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂ => N⁶-methyl-L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60218] N⁶-methyl-L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60219] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶-methyl-L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60221] N⁶-methyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂ => L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60222] L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂ => N⁶-methyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60223] N⁶-methyl-L-lysyl⁴-[histone H3] + 2-oxoglutarate + O₂ <=> L-lysyl⁴-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60225] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 2 2-oxoglutarate + 2 O₂ => N⁶-methyl-L-lysyl²⁷-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60226] N⁶-methyl-L-lysyl²⁷-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:60227] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 2 2-oxoglutarate + 2 O₂ <=> N⁶-methyl-L-lysyl²⁷-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60229] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂ => N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60230] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60231] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60233] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂ => N⁶-methyl-L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60234] N⁶-methyl-L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60235] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶-methyl-L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60237] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂ => N⁶-methyl-L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60238] N⁶-methyl-L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:60239] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 2 2-oxoglutarate + 2 O₂ <=> N⁶-methyl-L-lysyl³⁶-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:60241] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂ => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60242] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60243] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 2-oxoglutarate + O₂ <=> N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60921] an N³-methylcytidine in mRNA + 2-oxoglutarate + O₂ => a cytidine in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60922] a cytidine in mRNA + formaldehyde + succinate + CO₂ => an N³-methylcytidine in mRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:60923] an N³-methylcytidine in mRNA + 2-oxoglutarate + O₂ <=> a cytidine in mRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60925] N⁶-methyl-L-lysyl-[protein] + 2-oxoglutarate + O₂ => L-lysyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:60926] L-lysyl-[protein] + formaldehyde + succinate + CO₂ => N⁶-methyl-L-lysyl-[protein] + 2-oxoglutarate + O₂
• [Rhea:RHEA:60927] N⁶-methyl-L-lysyl-[protein] + 2-oxoglutarate + O₂ <=> L-lysyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:61949] N⁶,N⁶-dimethyl-L-lysyl-[protein] + 2-oxoglutarate + O₂ => N⁶-methyl-L-lysyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:61950] N⁶-methyl-L-lysyl-[protein] + formaldehyde + succinate + CO₂ => N⁶,N⁶-dimethyl-L-lysyl-[protein] + 2-oxoglutarate + O₂
• [Rhea:RHEA:61951] N⁶,N⁶-dimethyl-L-lysyl-[protein] + 2-oxoglutarate + O₂ <=> N⁶-methyl-L-lysyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:61953] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + 2-oxoglutarate + O₂ => N⁶,N⁶-dimethyl-L-lysyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:61954] N⁶,N⁶-dimethyl-L-lysyl-[protein] + formaldehyde + succinate + CO₂ => N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + 2-oxoglutarate + O₂
• [Rhea:RHEA:61955] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + 2-oxoglutarate + O₂ <=> N⁶,N⁶-dimethyl-L-lysyl-[protein] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:67801] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2 2-oxoglutarate + 2 O₂ => L-lysyl²⁷-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:67802] L-lysyl²⁷-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂ => N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2 2-oxoglutarate + 2 O₂
• [Rhea:RHEA:67803] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2 2-oxoglutarate + 2 O₂ <=> L-lysyl²⁷-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO₂
• [Rhea:RHEA:67805] N⁶-methyl-L-lysyl²⁰-[histone H4] + 2-oxoglutarate + O₂ => L-lysyl²⁰-[histone H4] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:67806] L-lysyl²⁰-[histone H4] + formaldehyde + succinate + CO₂ => N⁶-methyl-L-lysyl²⁰-[histone H4] + 2-oxoglutarate + O₂
• [Rhea:RHEA:67807] N⁶-methyl-L-lysyl²⁰-[histone H4] + 2-oxoglutarate + O₂ <=> L-lysyl²⁰-[histone H4] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:67833] N⁶-methyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂ => L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:67834] L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂ => N⁶-methyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂
• [Rhea:RHEA:67835] N⁶-methyl-L-lysyl²⁷-[histone H3] + 2-oxoglutarate + O₂ <=> L-lysyl²⁷-[histone H3] + formaldehyde + succinate + CO₂
• [Rhea:RHEA:79020] N¹-methyladenosine⁵⁸ in tRNA + 2-oxoglutarate + O₂ => adenosine⁵⁸ in tRNA + formaldehyde + succinate + CO₂
• [Rhea:RHEA:79021] adenosine⁵⁸ in tRNA + formaldehyde + succinate + CO₂ => N¹-methyladenosine⁵⁸ in tRNA + 2-oxoglutarate + O₂
• [Rhea:RHEA:79022] N¹-methyladenosine⁵⁸ in tRNA + 2-oxoglutarate + O₂ <=> adenosine⁵⁸ in tRNA + formaldehyde + succinate + CO₂

Metabolites

Substrates

metabolite	compartment	Structure

Products

metabolite	compartment	Structure
Formula:	Cytoplasm
Formaldehyde Formula: CH2O	Cytoplasm
succinate(2-) Formula: C4H4O4	Cytoplasm
CO2 Formula: CO2	Cytoplasm
Formula:	Cytoplasm
2-Oxoglutarate Formula: C5H6O5	Cytoplasm
Oxygen Formula: O2	Cytoplasm