数据之源，洞见之始

BioCyc:TRANS-RXN0-527

In the acidic pH of the bacterial periplasm, unconjugated bile acids exist largely in an uncharged, protonated form and can diffuse across the cytoplasmic membrane |CITS: [9098046]|. Their detergent properties are toxic to cells; the |FRAME: TRANS-CPLX-201 "AcrAB-TolC"| efflux system and the |FRAME: YJIO-MONOMER "MdtM"| efflux antiporter both contribute to E. coli's intrinsic resistance to bile acids |CITS: [9098046], [24684269]|. Additionally the presence of a |FRAME: 7-ALPHA-HYDROXYSTEROID-DEH-CPLX| in E. coli raises the possibility of detoxification through further metabolism |CITS: [9098046]|.