nsp5
K25926 nsp5; Alphacoronavirus 3C-like proteinase [EC:3.4.22.-]
Protein Function: Alphacoronavirus 3C-like proteinase [EC:3.4.22.-]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R09845 | CAAX protease | S-Farnesyl protein + H2O <=> Protein C-terminal S-farnesyl-L-cysteine + Peptide |
| BioCyc:RXN-21068 | Protein-with-LAXTG-motif + WATER + CPD-12106 --> Protein-with-LAXTG-G5-peptidoglycan + Protein-With-N-Terminal-Gly | |
| BioCyc:RXN-11144 | WATER + Protein-with-sequence-SGVTFQGKFKK --> Protein-with-sequence-SGVFTQ + Protein-with-sequence-GKFKK | |
| BioCyc:RXN-11138 | WATER + Protein-with-sequence-TSAVLQSGFRK-NH2 --> Protein-with-sequence-TSAVLQ + Protein-with-sequence-SGFRK-NH2 | TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing. In peptidase family C30. |