PDHA, pdhA
K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Protein Function: pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R00014 | pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating) | 2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270 |
| KEGG:R01699 | pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) | pyruvate dehydrogenase complex: pyruvate dehydrogenase |
| KEGG:R03270 | C05125 + C15972<=>C16255 + C00068 | 2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699) |
| BioCyc:RXN0-1134 | PYRUVATE + Pyruvate-dehydrogenase-lipoate + PROTON --> Pyruvate-dehydrogenase-acetylDHlipoyl + CARBON-DIOXIDE | |
| BioCyc:PYRUVATEDECARB-RXN | PROTON + PYRUVATE + LIPOAMIDE --> S-ACETYLDIHYDROLIPOAMIDE + CARBON-DIOXIDE | Note: Lipoamide is used to substitute for lipoate in assays conducted in vitro. |
| Rhea:RHEA:19190 | N6-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ => N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2 | |
| Rhea:RHEA:19191 | N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2 => N6-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ | |
| Rhea:RHEA:19192 | N6-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ <=> N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2 |