Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
putrescine biosynthesis I

Accession ID: BioCyc:LEISH_PWY-40		 -
superpathway of ornithine degradation

Accession ID: BioCyc:TRYPANO_ORNDEG-PWY		 -
putrescine degradation I

Accession ID: BioCyc:TRYPANO_PUTDEG-PWY		 -
spermine biosynthesis II

Accession ID: BioCyc:TRYPANO_ORNSPNANA-PWY		 -
spermidine biosynthesis I

Accession ID: BioCyc:TRYPANO_BSUBPOLYAMSYN-PWY		 -
superpathway of polyamine biosynthesis I

Accession ID: BioCyc:LEISH_POLYAMSYN-PWY
  • 10.1007/s00726-007-0537-9
  • 10.1016/j.cca.2005.02.006
  • 10.1128/aac.01193-06
 Heby O, Persson L, Rentala M. Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. Amino Acids. 2007 Aug;33(2):359–66. doi: 10.1007/s00726-007-0537-9. PMID: 17610127.; Roberts SC, Jiang Y, Gasteier J, Frydman B, Marton LJ, Heby O, Ullman B. Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. Antimicrob Agents Chemother. 2007 Feb;51(2):438–45. PMID: 17116678; PMCID: PMC1797743.; Reguera RM, Tekwani BL, Balaña-Fouce R. Polyamine transport in parasites: A potential target for new antiparasitic drug development. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2005 Feb;140(2):151–64. doi: 10.1016/j.cca.2005.02.006.
putrescine degradation II

Accession ID: BioCyc:TRYPANO_PWY0-1221		 -
arginine degradation III (arginine decarboxylase/agmatinase pathway)

Accession ID: BioCyc:TRYPANO_PWY0-823		 -
superpathway of polyamine biosynthesis II

Accession ID: BioCyc:TRYPANO_POLYAMINSYN3-PWY		 -
superpathway of arginine and polyamine biosynthesis

Accession ID: BioCyc:TRYPANO_ARG+POLYAMINE-SYN		 -
putrescine biosynthesis I

Accession ID: BioCyc:TRYPANO_PWY-40		 -
polyamine biosynthesis

Accession ID: BioCyc:CALBI_POLYAMSYN-YEAST-PWY
  • 10.1002/(sici)1097-0061(199711)13:14<1383::aid-yea189>3.0.co;2-m
  • 10.1007/s002940050254
  • 10.1016/0378-1097(89)90202-4
  • 10.1016/s0378-1119(98)00027-4
  • 10.1074/jbc.m009804200
  • 10.1099/00221287-136-10-1937
  • 10.1128/iai.67.9.4870-4878.1999
  • 10.1248/bpb.27.890
 Ueno Y, Fukumatsu M, Ogasawara A, Watanabe T, Mikami T, Matsumoto T. Hyphae Formation of Candida albicans Is Regulated by Polyamines. Biological & Pharmaceutical Bulletin. 2004;27(6):890–2. doi: 10.1248/bpb.27.890.; White WH, Gunyuzlu PL, Toyn JH. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem. 2001 Apr 06;276(14):10794–800. doi: 10.1074/jbc.m009804200. PMID: 11154694.; Herrero AB, Lo´pez MC, Garci´a S, Schmidt A, Spaltmann F, Ruiz-Herrera J, Dominguez A. Control of Filament Formation in Candida albicans by Polyamine Levels. Infect Immun. 1999 Sep;67(9):4870–8. doi: 10.1128/iai.67.9.4870-4878.1999.; Hamasaki-Katagiri N, Katagiri Y, Tabor CW, Tabor H. Spermine is not essential for growth of Saccharomyces cerevisiae: identification of the SPE4 gene (spermine synthase) and characterization of a spe4 deletion mutant. Gene. 1998 Apr 14;210(2):195–201. doi: 10.1016/s0378-1119(98)00027-4. PMID: 9573363.; McNemar MD, Gorman JA, Buckley HR. Isolation and sequence of the gene encoding ornithine decarboxylase, SPE1, from Candida albicans by complementation of a spe1 delta strain of Saccharomyces cerevisiae. Yeast. 1997 Nov;13(14):1383–9. doi: 10.1002/(sici)1097-0061(199711)13:14<1383::aid-yea189>3.0.co;2-m. PMID: 9392083.; López MC, García S, Ruiz-Herrera J, Domínguez A. The ornithine decarboxylase gene from Candida albicans. Sequence analysis and expression during dimorphism. Curr Genet. 1997 Aug;32(2):108–14. doi: 10.1007/s002940050254. PMID: 9294258.; Martinez JP, Lopez-Ribot JL, Gil ML, Sentandreu R, Ruiz-Herrera J. Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprotein composition of the cell wall. Journal of General Microbiology. 1990 Oct 01;136(10):1937–43. doi: 10.1099/00221287-136-10-1937.; Bezjak V, al-Nakib T, Chandy R, Verghese R. Cell-constituent polyamines in Candida species and new biotyping of Candida albicans, Candida tropicalis and Candida parapsilosis strains. J Med Vet Mycol. 1990;28(4):267–73. PMID: 2269908.; Hamana K, Matsuzaki S, Hosaka K, Yamashita S. Interconversion of polyamines in wild-type strains and mutants of yeasts and the effects of polyamines on their growth. FEMS Microbiol Lett. 1989 Oct 01;52(1-2):231–6. doi: 10.1016/0378-1097(89)90202-4. PMID: 2689281.; Pfaller MA, Riley J, Gerarden T. Polyamine depletion and growth inhibition in Candida albicans and Candida tropicalis by alpha-difluoromethylornithine and cyclohexylamine. J Med Vet Mycol. 1988 Apr;26(2):119–26. PMID: 3138402.
methionine salvage pathway

Accession ID: BioCyc:LEISH_PWY3IU-1026
  • 10.1016/j.molbiopara.2006.11.013
 Reguera RM, Redondo CM, Pérez-Pertejo Y, Balaña-Fouce R. S-Adenosylmethionine in protozoan parasites: Functions, synthesis and regulation. Molecular and Biochemical Parasitology. 2007 Mar;152(1):1–10. doi: 10.1016/j.molbiopara.2006.11.013.
putrescine biosynthesis III

Accession ID: BioCyc:LEISH_PWY-46
  • 10.1074/jbc.274.6.3781
 Jiang Y, Roberts SC, Jardim A, Carter NS, Shih S, Ariyanayagam M, Fairlamb AH, Ullman B. Ornithine Decarboxylase Gene Deletion Mutants of Leishmania donovani. Journal of Biological Chemistry. 1999 Feb;274(6):3781–8. doi: 10.1074/jbc.274.6.3781.
putrescine biosynthesis III

Accession ID: BioCyc:TRYPANO_PWY-46		 -
spermidine biosynthesis I

Accession ID: BioCyc:LEISH_BSUBPOLYAMSYN-PWY
  • 10.1016/s0166-6851(01)00293-6
  • 10.1074/jbc.m110118200
 Roberts SC, Scott J, Gasteier JE, Jiang Y, Brooks B, Jardim A, Carter NS, Heby O, Ullman B. S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers. J Biol Chem. 2002 Feb 22;277(8):5902–9. doi: 10.1074/jbc.m110118200. PMID: 11734561.; Roberts SC, Jiang Y, Jardim A, Carter NS, Heby O, Ullman B. Genetic analysis of spermidine synthase from Leishmania donovani. Mol Biochem Parasitol. 2001 Jul;115(2):217–26. doi: 10.1016/s0166-6851(01)00293-6. PMID: 11420108.
superpathway of arginine and ornithine degradation

Accession ID: BioCyc:TRYPANO_ORNARGDEG-PWY		 -
superpathway of arginine, putrescine, and 4-aminobutyrate degradation

Accession ID: BioCyc:TRYPANO_ARGDEG-PWY		 -
superpathway of polyamine biosynthesis I

Accession ID: BioCyc:TRYPANO_POLYAMSYN-PWY		 -
putrescine biosynthesis II

Accession ID: BioCyc:TRYPANO_PWY-43		 -