oleanolate biosynthesis
Accession ID: BioCyc:META_PWY-7069 |
10.1002/jat.272510.1002/mc.2191910.1007/s00425-012-1712-010.1016/j.jep.2008.09.00110.1073/pnas.080387610510.1093/pcp/pcr14610.1105/tpc.107.05663010.1105/tpc.110.08268510.1248/bpb.32.81810.3390/molecules17033524
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Huang L, Li J, Ye H, Li C, Wang H, Liu B, Zhang Y. Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta. 2012 Nov;236(5):1571–81. doi: 10.1007/s00425-012-1712-0. PMID: 22837051.; Wei J, Liu M, Liu H, Wang H, Wang F, Zhang Y, Han L, Lin X. Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells. J Appl Toxicol. 2013 Aug;33(8):756–65. doi: 10.1002/jat.2725. PMID: 22678527.; Shih W, Yu F, Chang C, Liao M, Wu H, Lin P. Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. Molecular Carcinogenesis. 2012 Apr 30;52(10):800–12. doi: 10.1002/mc.21919.; Yoo KY, Park SY. Terpenoids as potential anti-Alzheimer's disease therapeutics. Molecules. 2012 Mar 19;17(3):3524–38. PMID: 22430119; PMCID: PMC6268347.; Seki H, Sawai S, Ohyama K, Mizutani M, Ohnishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, Muranaka T. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell. 2011 Nov;23(11):4112–23. PMID: 22128119; PMCID: PMC3246328.; Fukushima EO, Seki H, Ohyama K, Ono E, Umemoto N, Mizutani M, Saito K, Muranaka T. CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant Cell Physiol. 2011 Dec;52(12):2050–61. doi: 10.1093/pcp/pcr146. PMID: 22039103.; Liu Y, Cai Y, Zhao Z, Wang J, Li J, Xin W, Xia G, Xiang F. Cloning and Functional Analysis of a β-Amyrin Synthase Gene Associated with Oleanolic Acid Biosynthesis in Gentiana straminea MAXIM. Biological & Pharmaceutical Bulletin. 2009;32(5):818–24. doi: 10.1248/bpb.32.818.; Fontanay S, Grare M, Mayer J, Finance C, Duval RE. Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. J Ethnopharmacol. 2008 Nov 20;120(2):272–6. doi: 10.1016/j.jep.2008.09.001. PMID: 18835348.; Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T. Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14204–9. PMID: 18779566; PMCID: PMC2532699.; Murata J, Roepke J, Gordon H, De Luca V. The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell. 2008 Mar;20(3):524–42. PMID: 18326827; PMCID: PMC2329939. |
oleanolate biosynthesis
Accession ID: PlantCyc:PLANT_PWY-7069 |
10.1002/jat.272510.1002/mc.2191910.1016/j.jep.2008.09.00110.1073/pnas.080387610510.1093/pcp/pcr14610.1105/tpc.110.08268510.1248/bpb.32.81810.3390/molecules17033524
|
Wei J, Liu M, Liu H, Wang H, Wang F, Zhang Y, Han L, Lin X. Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells. J Appl Toxicol. 2013 Aug;33(8):756–65. doi: 10.1002/jat.2725. PMID: 22678527.; Shih W, Yu F, Chang C, Liao M, Wu H, Lin P. Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. Molecular Carcinogenesis. 2012 Apr 30;52(10):800–12. doi: 10.1002/mc.21919.; Yoo KY, Park SY. Terpenoids as potential anti-Alzheimer's disease therapeutics. Molecules. 2012 Mar 19;17(3):3524–38. PMID: 22430119; PMCID: PMC6268347.; Seki H, Sawai S, Ohyama K, Mizutani M, Ohnishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, Muranaka T. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell. 2011 Nov;23(11):4112–23. PMID: 22128119; PMCID: PMC3246328.; Fukushima EO, Seki H, Ohyama K, Ono E, Umemoto N, Mizutani M, Saito K, Muranaka T. CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant Cell Physiol. 2011 Dec;52(12):2050–61. doi: 10.1093/pcp/pcr146. PMID: 22039103.; Liu Y, Cai Y, Zhao Z, Wang J, Li J, Xin W, Xia G, Xiang F. Cloning and Functional Analysis of a β-Amyrin Synthase Gene Associated with Oleanolic Acid Biosynthesis in Gentiana straminea MAXIM. Biological & Pharmaceutical Bulletin. 2009;32(5):818–24. doi: 10.1248/bpb.32.818.; Fontanay S, Grare M, Mayer J, Finance C, Duval RE. Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. J Ethnopharmacol. 2008 Nov 20;120(2):272–6. doi: 10.1016/j.jep.2008.09.001. PMID: 18835348.; Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T. Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14204–9. PMID: 18779566; PMCID: PMC2532699. |