Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| tetrahydroxyxanthone biosynthesis (from benzoate) Accession ID: PlantCyc:PLANT_PWY-5001 |
|
Nualkaew N, Morita H, Shimokawa Y, Kinjo K, Kushiro T, De-Eknamkul W, Ebizuka Y, Abe I. Benzophenone synthase from Garcinia mangostana L. pericarps. Phytochemistry. 2012 May;77():60–9. doi: 10.1016/j.phytochem.2012.02.002. PMID: 22390826.; Jiang DJ, Dai Z, Li YJ. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovasc Drug Rev. 2004;22(2):91–102. doi: 10.1111/j.1527-3466.2004.tb00133.x. PMID: 15179447.; Liu B, Falkenstein-Paul H, Schmidt W, Beerhues L. Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases. The Plant Journal. 2003 Jun;34(6):847–55. doi: 10.1046/j.1365-313x.2003.01771.x.; Jankovic T, Krstic D, Savikin-Fodulovic K, Menkovic N, Grubisic D. Xanthones and secoiridoids from hairy root cultures of Centaurium erythraea and C. pulchellum. Planta Med. 2002 Oct;68(10):944–6. doi: 10.1055/s-2002-34927. PMID: 12391565.; Beuerle T, Pichersky E. Purification and characterization of benzoate:coenzyme A ligase from Clarkia breweri. Archives of Biochemistry and Biophysics. 2002 Apr;400(2):258–64. doi: 10.1016/s0003-9861(02)00026-7.; Abd El-Mawla AM, Beerhues L. Benzoic acid biosynthesis in cell cultures of Hypericum androsaemum. Planta. 2002 Mar;214(5):727–33. doi: 10.1007/s004250100657. PMID: 11882941.; Abd El-Mawla AM, Schmidt W, Beerhues L. Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN. Planta. 2001 Jan;212(2):288–93. doi: 10.1007/s004250000394. PMID: 11216850.; Schmidt W, Abd el-Mawla AM, Wolfender JL, Hostettmann K, Beerhues L. Xanthones in cell cultures of Hypericum androsaemum. Planta Med. 2000 May;66(4):380–1. doi: 10.1055/s-2000-8542. PMID: 10865463.; Peres V, Nagem TJ, de Oliveira FF. Tetraoxygenated naturally occurring xanthones. Phytochemistry. 2000 Dec;55(7):683–710. doi: 10.1016/s0031-9422(00)00303-4. PMID: 11190384.; Schmidt W, Peters S, Beerhues L. Xanthone 6-hydroxylase from cell cultures of Centaurium erythraea RAFN and Hypericum androsaemium L. Phytochemistry. 2000 Feb;53(4):427–31. doi: 10.1016/s0031-9422(99)00566-x. PMID: 10731018.; Ito C, Itoigawa M, Furukawa H, Rao KS, Enjo F, Bu P, Takayasu J, Tokuda H, Nishino H. Xanthones as inhibitors of Epstein-Barr virus activation. Cancer Lett. 1998 Oct 23;132(1-2):113–7. doi: 10.1016/s0304-3835(98)00173-6. PMID: 10397461.; Schmidt W, Beerhues L. Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L. FEBS Lett. 1997 Dec 29;420(2-3):143–6. doi: 10.1016/s0014-5793(97)01507-x. PMID: 9459298. |
| superpathway of tetrahydroxyxanthone biosynthesis Accession ID: PlantCyc:PLANT_PWY-13 |
|
Nualkaew N, Morita H, Shimokawa Y, Kinjo K, Kushiro T, De-Eknamkul W, Ebizuka Y, Abe I. Benzophenone synthase from Garcinia mangostana L. pericarps. Phytochemistry. 2012 May;77():60–9. doi: 10.1016/j.phytochem.2012.02.002. PMID: 22390826.; Jiang DJ, Dai Z, Li YJ. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovasc Drug Rev. 2004;22(2):91–102. doi: 10.1111/j.1527-3466.2004.tb00133.x. PMID: 15179447.; Wang CZ, Maier UH, Keil M, Zenk MH, Bacher A, Rohdich F, Eisenreich W. Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata. Eur J Biochem. 2003 Jul;270(14):2950–8. doi: 10.1046/j.1432-1033.2003.03669.x. PMID: 12846828.; Liu B, Falkenstein-Paul H, Schmidt W, Beerhues L. Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases. The Plant Journal. 2003 Jun;34(6):847–55. doi: 10.1046/j.1365-313x.2003.01771.x.; Jankovic T, Krstic D, Savikin-Fodulovic K, Menkovic N, Grubisic D. Xanthones and secoiridoids from hairy root cultures of Centaurium erythraea and C. pulchellum. Planta Med. 2002 Oct;68(10):944–6. doi: 10.1055/s-2002-34927. PMID: 12391565.; Beuerle T, Pichersky E. Purification and characterization of benzoate:coenzyme A ligase from Clarkia breweri. Archives of Biochemistry and Biophysics. 2002 Apr;400(2):258–64. doi: 10.1016/s0003-9861(02)00026-7.; Abd El-Mawla AM, Beerhues L. Benzoic acid biosynthesis in cell cultures of Hypericum androsaemum. Planta. 2002 Mar;214(5):727–33. doi: 10.1007/s004250100657. PMID: 11882941.; Abd El-Mawla AM, Schmidt W, Beerhues L. Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN. Planta. 2001 Jan;212(2):288–93. doi: 10.1007/s004250000394. PMID: 11216850.; Peres V, Nagem TJ, de Oliveira FF. Tetraoxygenated naturally occurring xanthones. Phytochemistry. 2000 Dec;55(7):683–710. doi: 10.1016/s0031-9422(00)00303-4. PMID: 11190384.; Schmidt W, Peters S, Beerhues L. Xanthone 6-hydroxylase from cell cultures of Centaurium erythraea RAFN and Hypericum androsaemium L. Phytochemistry. 2000 Feb;53(4):427–31. doi: 10.1016/s0031-9422(99)00566-x. PMID: 10731018.; Ito C, Itoigawa M, Furukawa H, Rao KS, Enjo F, Bu P, Takayasu J, Tokuda H, Nishino H. Xanthones as inhibitors of Epstein-Barr virus activation. Cancer Lett. 1998 Oct 23;132(1-2):113–7. doi: 10.1016/s0304-3835(98)00173-6. PMID: 10397461.; Schmidt W, Beerhues L. Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L. FEBS Lett. 1997 Dec 29;420(2-3):143–6. doi: 10.1016/s0014-5793(97)01507-x. PMID: 9459298. |