Pathways Knowlegdes

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Pathway DOIs Note
superpathway of central carbon metabolism

Accession ID: BioCyc:LEISH_PWY3IU-99
  • 10.1073/pnas.0603539103
 Sernee MF, Ralton JE, Dinev Z, Khairallah GN, O’Hair RA, Williams SJ, McConville MJ. Leishmania ß-1,2-mannan is assembled on a mannose-cyclic phosphate primer. Proc. Natl. Acad. Sci. U.S.A. 2006 Jun 20;103(25):9458–63. doi: 10.1073/pnas.0603539103.
TCA cycle

Accession ID: BioCyc:LEISH_TCA
  • 10.1016/j.molbiopara.2006.04.010
  • 10.2307/3285729
 Leroux A, Fleming-Canepa X, Aranda A, Maugeri D, Cazzulo JJ, Sánchez MA, Nowicki C. Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp. Molecular and Biochemical Parasitology. 2006 Sep;149(1):74–85. doi: 10.1016/j.molbiopara.2006.04.010.; Louassini M, Foulquie M, Benitez R, Adroher J. Citric-Acid Cycle Key Enzyme Activities during In vitro Growth and Metacyclogenesis of Leishmania infantum Promastigotes. The Journal of Parasitology. 1999 Aug;85(4):595. doi: 10.2307/3285729.
gluconeogenesis I

Accession ID: BioCyc:LEISH_GLUCONEO-PWY
  • 10.1073/pnas.0509196103
  • 10.1074/jbc.m603265200
 Rodríguez-Contreras D, Landfear SM. Metabolic Changes in Glucose Transporter-deficient Leishmania mexicana and Parasite Virulence. Journal of Biological Chemistry. 2006 Jul;281(29):20068–76. doi: 10.1074/jbc.m603265200.; Naderer T, Ellis MA, Sernee MF, De Souza DP, Curtis J, Handman E, McConville MJ. Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc. Natl. Acad. Sci. U.S.A. 2006 Apr 04;103(14):5502–7. doi: 10.1073/pnas.0509196103.
folate metabolism

Accession ID: BioCyc:LEISH_PWY3IU-235
  • 10.1016/j.pt.2007.02.004
  • 10.1016/s0020-7519(01)00346-0
  • 10.1111/j.1365-2958.2009.06610.x
 Murta SMF, Vickers TJ, Scott DA, Beverley SM. Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential inLeishmania major. Molecular Microbiology. 2009 Mar;71(6):1386–401. doi: 10.1111/j.1365-2958.2009.06610.x.; Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.; Ouellette M, Drummelsmith J, El Fadili A, Kündig C, Richard D, Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. International Journal for Parasitology. 2002 Apr;32(4):385–98. doi: 10.1016/s0020-7519(01)00346-0.
trypanothione redox reactions

Accession ID: BioCyc:LEISH_PWY3IU-1025
  • 10.1016/0166-6851(94)00034-4
  • 10.1016/s0166-6851(98)00122-4
 Levick MP, Tetaud E, Fairlamb AH, Blackwell JM. Identification and characterisation of a functional peroxidoxin from Leishmania major1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank™ and DDJB databases under the accession number AF069386.1. Molecular and Biochemical Parasitology. 1998 Oct;96(1-2):125–37. doi: 10.1016/s0166-6851(98)00122-4.; Taylor MC, Kelly JM, Chapman CJ, Fairlamb AH, Miles MA. The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase. Molecular and Biochemical Parasitology. 1994 Apr;64(2):293–301. doi: 10.1016/0166-6851(94)00034-4.
sphingolipid metabolism

Accession ID: BioCyc:LEISH_SPHINGOLIPID-SYN-PWY
  • 10.1038/sj.emboj.7601565
  • 10.1111/j.1365-2958.2004.04208.x
 Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21;26(4):1094–104. PMID: 17290222; PMCID: PMC1852826.; Denny PW, Smith DF. Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa. Mol Microbiol. 2004 Aug;53(3):725–33. doi: 10.1111/j.1365-2958.2004.04208.x. PMID: 15255887.
very long chain fatty acid biosynthesis

Accession ID: BioCyc:LEISH_PWY-5080
  • 10.1038/nrmicro1617
  • 10.1098/rstb.1997.0113
 Lee SH, Stephens JL, Englund PT. A fatty-acid synthesis mechanism specialized for parasitism. Nat Rev Microbiol. 2007 Apr;5(4):287–97. doi: 10.1038/nrmicro1617. PMID: 17363967.; Ferguson MA. The surface glycoconjugates of trypanosomatid parasites. Philos Trans R Soc Lond B Biol Sci. 1997 Sep 29;352(1359):1295–302. PMID: 9355120; PMCID: PMC1692025.
oxaloacetate degradation to pyruvate

Accession ID: BioCyc:LEISH_PWY3IU-39
  • 10.1016/j.molbiopara.2006.04.010
  • 10.1016/j.pt.2007.02.004
 Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.; Leroux A, Fleming-Canepa X, Aranda A, Maugeri D, Cazzulo JJ, Sánchez MA, Nowicki C. Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp. Molecular and Biochemical Parasitology. 2006 Sep;149(1):74–85. doi: 10.1016/j.molbiopara.2006.04.010.
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

Accession ID: BioCyc:LEISH_PWY-5651		 -
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

Accession ID: BioCyc:TRYPANO_PWY-5651		 -
respiration (anaerobic)

Accession ID: BioCyc:TRYPANO_ANARESP1-PWY		 -
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass

Accession ID: BioCyc:TRYPANO_GLYCOLYSIS-TCA-GLYOX-BYPASS		 -
aspartate superpathway

Accession ID: BioCyc:TRYPANO_PWY0-781		 -
superpathway of lysine, threonine and methionine biosynthesis II

Accession ID: BioCyc:TRYPANO_PWY-724		 -
isoleucine biosynthesis I

Accession ID: BioCyc:TRYPANO_PWY-3001		 -
mevalonate pathway I

Accession ID: BioCyc:TRYPANO_PWY-922		 -
formylTHF biosynthesis II

Accession ID: BioCyc:TRYPANO_PWY-3841		 -
flavin biosynthesis I (bacteria and plants)

Accession ID: BioCyc:TRYPANO_RIBOSYN2-PWY		 -
glutathione redox reactions I

Accession ID: BioCyc:TRYPANO_PWY-4081		 -
isoleucine biosynthesis I (from threonine)

Accession ID: BioCyc:TRYPANO_ILEUSYN-PWY		 -