Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| S-adenosylmethionine cycle Accession ID: BioCyc:CALBI_PWY-5041 |
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Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol. 2006 Sep;8(9):1382–91. doi: 10.1111/j.1462-5822.2006.00761.x. PMID: 16848788.; Suliman HS, Sawyer GM, Appling DR, Robertus JD. Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 2005 Sep;441(1):56–63. doi: 10.1016/j.abb.2005.06.016.; Eschrich D, Buchhaupt M, Kötter P, Entian KD. Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet. 2002 Feb;40(5):326–38. doi: 10.1007/s00294-001-0269-4. PMID: 11935223.; Thomas D, Surdin-Kerjan Y. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 1997 Dec;61(4):503–32. doi: 10.1128/mmbr.61.4.503-532.1997.; Mountain HA, Byström AS, Larsen JT, Korch C. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast. 1991 Nov;7(8):781–803. doi: 10.1002/yea.320070804. PMID: 1789001.; Shapiro SK, Schlenk F. Conversion of 5'-Methylthioadenosine into S-adenosylmethionine by yeast cells. Biochimica et Biophysica Acta (BBA) - General Subjects. 1980 Dec 01;633(2):176–80. doi: 10.1016/0304-4165(80)90403-1.; Schlenk F, Hannum CH, Ferro AJ. Biosynthesis of adenosyl-d-methionine and adenosyl-2-methylmethionine by Candida utilis. Archives of Biochemistry and Biophysics. 1978 Apr;187(1):191–6. doi: 10.1016/0003-9861(78)90022-x.; Holcomb ER, Shapiro SK. Assay and regulation of S-adenosylmethionine synthetase in Saccharomyces cerevisiae and Candida utilis. J Bacteriol. 1975 Jan;121(1):267–71. doi: 10.1128/jb.121.1.267-271.1975.; Nakamura KD, Schlenk F. Examination of Isolated Yeast Cell Vacuoles for Active Transport. J Bacteriol. 1974 Apr;118(1):314–6. doi: 10.1128/jb.118.1.314-316.1974.; Balish E. S-adenosylmethionine metabolism by members of the genus Candida. Can J Microbiol. 1973 Oct;19(10):1297–303. doi: 10.1139/m73-208. PMID: 4587092.; Schlenk F, Zydek-Cwick CR, Dainko JL. 5'-methylthioadenosine and related compounds as precursors of S-adenosylmethionine in yeast. Biochimica et Biophysica Acta (BBA) - General Subjects. 1973 Sep;320(2):357–62. doi: 10.1016/0304-4165(73)90316-4.; Balish E. Methionine biosynthesis and S-adenosylmethionine degradation during an induced morphogenesis of Candida albicans. Can J Microbiol. 1973 Jul;19(7):847–53. doi: 10.1139/m73-135. PMID: 4580452.; Mardon DN. In vivo synthesis of sulfur containing amino acids in Candida albicans. Can J Microbiol. 1973 Feb;19(2):155–61. doi: 10.1139/m73-024. PMID: 4572423.; Salem AR, Foster MA. The microbial biosynthesis of methionine. Biochem J. 1972 May;127(5):845–53. PMID: 4627687; PMCID: PMC1178794.; Mardon DN, Balish E. Methionine biosynthesis in Candida albicans. I. S-Adenosyl- |
| methionine biosynthesis Accession ID: BioCyc:CALBI_PWY3B3-43 |
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Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol. 2006 Sep;8(9):1382–91. doi: 10.1111/j.1462-5822.2006.00761.x. PMID: 16848788.; Suliman HS, Sawyer GM, Appling DR, Robertus JD. Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 2005 Sep;441(1):56–63. doi: 10.1016/j.abb.2005.06.016.; Ohwada J, Umeda I, Ontsuka H, Aoki Y, Shimma N. Synthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin. Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1703–5. doi: 10.1248/cpb.42.1703. PMID: 7954924.; Mountain HA, Byström AS, Larsen JT, Korch C. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast. 1991 Nov;7(8):781–803. doi: 10.1002/yea.320070804. PMID: 1789001.; Manning M, Snoddy CB, Fromtling RA. Comparative pathogenicity of auxotrophic mutants of Candida albicans. Can J Microbiol. 1984 Jan;30(1):31–5. doi: 10.1139/m84-005. PMID: 6370397.; Kakar SN, Magee PT. Genetic analysis of Candida albicans: identification of different isoleucine-valine, methionine, and arginine alleles by complementation. J Bacteriol. 1982 Sep;151(3):1247–52. doi: 10.1128/jb.151.3.1247-1252.1982.; Balish E. Methionine biosynthesis and S-adenosylmethionine degradation during an induced morphogenesis of Candida albicans. Can J Microbiol. 1973 Jul;19(7):847–53. doi: 10.1139/m73-135. PMID: 4580452.; Mardon DN. In vivo synthesis of sulfur containing amino acids in Candida albicans. Can J Microbiol. 1973 Feb;19(2):155–61. doi: 10.1139/m73-024. PMID: 4572423.; Mardon DN, Balish E. Methionine biosynthesis in Candida albicans. I. S-Adenosyl- |
| cysteine and homocysteine interconversion Accession ID: BioCyc:CALBI_PWY-801 |
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Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol. 2006 Sep;8(9):1382–91. doi: 10.1111/j.1462-5822.2006.00761.x. PMID: 16848788.; Murillo LA, Newport G, Lan C, Habelitz S, Dungan J, Agabian NM. Genome-Wide Transcription Profiling of the Early Phase of Biofilm Formation by Candida albicans. Eukaryot Cell. 2005 Sep;4(9):1562–73. doi: 10.1128/ec.4.9.1562-1573.2005.; Mulet JM, Alemany B, Ros R, Calvete JJ, Serrano R. Expression of a plant serine O-acetyltransferase in Saccharomyces cerevisiae confers osmotic tolerance and creates an alternative pathway for cysteine biosynthesis. Yeast. 2004 Mar;21(4):303–12. doi: 10.1002/yea.1076. PMID: 15042590.; Ono BI, Hazu T, Yoshida S, Kawato T, Shinoda S, Brzvwczy J, Paszewski A. Cysteine biosynthesis in Saccharomyces cerevisiae: a new outlook on pathway and regulation. Yeast. 1999 Sep 30;15(13):1365–75. doi: 10.1002/(sici)1097-0061(19990930)15:13<1365::aid-yea468>3.0.co;2-u. PMID: 10509018.; Thomas D, Surdin-Kerjan Y. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 1997 Dec;61(4):503–32. doi: 10.1128/mmbr.61.4.503-532.1997.; Morzycka E, Paszewski A. Cysteine and homocysteine synthesis in Saccharomycopsis lipolytica; identification and characterization of two cysteine synthases. Acta Biochim Pol. 1982;29(1-2):81–93. PMID: 7180327.; Paszewski A, Grabski J. On sulfhydrylation of O-acetylserine and O-acetylhomoserine in homocysteine synthesis in yeast. Acta Biochim Pol. 1976;23(4):321–4. PMID: 1015154.; Wain WH, Price MF, Cawson RA. A re-evaluation of the effect of cysteine or Candida albicans. Sabouraudia. 1975 Mar;13 Pt 1():74–82. PMID: 1092000.; Mardon DN. In vivo synthesis of sulfur containing amino acids in Candida albicans. Can J Microbiol. 1973 Feb;19(2):155–61. doi: 10.1139/m73-024. PMID: 4572423.; Schlenk F, Zydek CR. Observations on the metabolism of sulfur amino acid derivatives in yeast. Archives of Biochemistry and Biophysics. 1968 Mar;123(3):438–46. doi: 10.1016/0003-9861(68)90164-1. |
| folate transformations II Accession ID: BioCyc:CALBI_PWY-3841 |
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Navarro-Martínez MD, García-Cánovas F, Rodríguez-López JN. Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans. J Antimicrob Chemother. 2006 Jun;57(6):1083–92. doi: 10.1093/jac/dkl124. PMID: 16585130. |
| Trans-sulfuration, one-carbon metabolism and related pathways Accession ID: WikiPathways:WP2525 |
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Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metabolism. 2017 Jan;25(1):27–42. doi: 10.1016/j.cmet.2016.08.009. |
| MTHFR deficiency Accession ID: WikiPathways:WP4288 |
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James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr. 2002 Aug;132(8 Suppl):2361S–2366S. doi: 10.1093/jn/132.8.2361s. PMID: 12163693. |
| One-carbon metabolism and related pathways Accession ID: WikiPathways:WP1770 |
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| Methionine metabolism leading to sulfur amino acids and related disorders Accession ID: WikiPathways:WP4292 |
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Linnebank M, Lagler F, Muntau AC, Röschinger W, Olgemöller B, Fowler B, Koch HG. Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases. J Inherit Metab Dis. 2005;28(6):1167–8. doi: 10.1007/s10545-005-4497-5. PMID: 16435220. |
| Neurotransmitter clearance in synaptic cleft Accession ID: WikiPathways:WP3165 |
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Beck O, Helander A, Carlsson S, Borg S. Changes in serotonin metabolism during treatment with the aldehyde dehydrogenase inhibitors disulfiram and cyanamide. Pharmacol Toxicol. 1995 Nov;77(5):323–6. doi: 10.1111/j.1600-0773.1995.tb01035.x. PMID: 8778744. |
| One-carbon metabolism and related pathways Accession ID: WikiPathways:WP3940 |
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| Disorders of folate metabolism and transport Accession ID: WikiPathways:WP4259 |
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Zheng Y, Cantley LC. Toward a better understanding of folate metabolism in health and disease. J Exp Med. 2019 Feb 04;216(2):253–66. PMID: 30587505; PMCID: PMC6363433. |