Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| L-tryptophan degradation X (mammalian, via tryptamine) Accession ID: BioCyc:META_PWY-6307 |
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Yu A, Granvil CP, Haining RL, Krausz KW, Corchero J, Küpfer A, Idle JR, Gonzalez FJ. The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine. The Journal of Pharmacology and Experimental Therapeutics. 2003 Feb;304(2):539–46. doi: 10.1124/jpet.102.043786.; Mousseau DD. Tryptamine: a metabolite of tryptophan implicated in various neuropsychiatric disorders. Metab Brain Dis. 1993 Mar;8(1):1–44. doi: 10.1007/bf01000528. PMID: 8098507.; Susilo R, Höfle G, Rommelspacher H. Degradation of tryptamine in pig brain: Identification of a new condensation product. Biochemical and Biophysical Research Communications. 1987 Nov;148(3):1045–52. doi: 10.1016/s0006-291x(87)80237-1.; Yamada J, Sugimoto Y, Horisaka K. Determination of endogeneous indoleacetic acid and tryptophol in mouse brain by high performance liquid chromatography with fluorometric detection. Life Sci. 1983 Nov 14;33(20):2043–7. doi: 10.1016/0024-3205(83)90744-0. PMID: 6645790.; Jaeger CB, Teitelman G, Joh TH, Albert VR, Park DH, Reis DJ. Some neurons of the rat central nervous system contain aromatic-L-amino-acid decarboxylase but not monoamines. Science. 1983 Mar 11;219(4589):1233–5. doi: 10.1126/science.6131537. PMID: 6131537.; Young SN, Davis BA, Gauthier S. Precursors and metabolites of phenylethylamine, m and p-tyramine and tryptamine in human lumbar and cisternal cerebrospinal fluid. Journal of Neurology, Neurosurgery & Psychiatry. 1982 Jul 01;45(7):633–9. doi: 10.1136/jnnp.45.7.633.; Young SN, Gauthier S, Anderson GM, Purdy WC. Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs. Journal of Neurology, Neurosurgery & Psychiatry. 1980 May 01;43(5):438–45. doi: 10.1136/jnnp.43.5.438. |
| dopamine degradation Accession ID: BioCyc:META_PWY6666-2 |
|
Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev. 2004 Sep;56(3):331–49. doi: 10.1124/pr.56.3.1. PMID: 15317907. |
| superpathway of phenylethylamine degradation Accession ID: BioCyc:META_PWY-6071 |
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Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14390–5. PMID: 20660314; PMCID: PMC2922514.; Hanlon SP, Hill TK, Flavell MA, Stringfellow JM, Cooper RA. 2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression. Microbiology (Reading). 1997 Feb;143 ( Pt 2)():513–8. doi: 10.1099/00221287-143-2-513. PMID: 9043126.; Parrott S, Jones S, Cooper RA. 2-Phenylethylamine catabolism by Escherichia coli K12. J Gen Microbiol. 1987 Feb;133(2):347–51. doi: 10.1099/00221287-133-2-347. PMID: 3309152. |
| phenylethylamine degradation I Accession ID: BioCyc:ECO_2PHENDEG-PWY |
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Parrott S, Jones S, Cooper RA. 2-Phenylethylamine catabolism by Escherichia coli K12. J Gen Microbiol. 1987 Feb;133(2):347–51. doi: 10.1099/00221287-133-2-347. PMID: 3309152. |
| phenylethylamine degradation I Accession ID: BioCyc:META_2PHENDEG-PWY |
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Parrott S, Jones S, Cooper RA. 2-Phenylethylamine catabolism by Escherichia coli K12. J Gen Microbiol. 1987 Feb;133(2):347–51. doi: 10.1099/00221287-133-2-347. PMID: 3309152. |
| melatonin degradation II Accession ID: BioCyc:META_PWY-6399 |
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Hardeland R. Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites. Cellular and Molecular Life Sciences. 2008 Mar 17;65(13):2001–18. doi: 10.1007/s00018-008-8001-x.; Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab. 2008 Jan;19(1):17–24. doi: 10.1016/j.tem.2007.10.007. PMID: 18155917.; Grace MS, Besharse JC. Melatonin deacetylase activity in the pineal gland and brain of the lizards Anolis carolinensis and Sceloporus jarrovi. Neuroscience. 1994 Sep;62(2):615–23. doi: 10.1016/0306-4522(94)90393-x. PMID: 7530349.; Grace MS, Cahill GM, Besharse JC. Melatonin deacetylation: retinal vertebrate class distribution and Xenopus laevis tissue distribution. Brain Res. 1991 Sep 13;559(1):56–63. doi: 10.1016/0006-8993(91)90286-5. PMID: 1782560. |
| superpathway of phenylethylamine degradation Accession ID: BioCyc:ECO_PWY-6071 |
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| dopamine degradation Accession ID: BioCyc:HUMAN_PWY6666-2 |
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Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev. 2004 Sep;56(3):331–49. doi: 10.1124/pr.56.3.1. PMID: 15317907. |
| superpathway of melatonin degradation Accession ID: BioCyc:META_PWY-6402 |
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Hardeland R, Tan D, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. Journal of Pineal Research. 2009 Aug 02;47(2):109–26. doi: 10.1111/j.1600-079x.2009.00701.x.; Hardeland R. Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites. Cellular and Molecular Life Sciences. 2008 Mar 17;65(13):2001–18. doi: 10.1007/s00018-008-8001-x.; Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab. 2008 Jan;19(1):17–24. doi: 10.1016/j.tem.2007.10.007. PMID: 18155917.; Tan D, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? Journal of Pineal Research. 2006 Nov 29;42(1):28–42. doi: 10.1111/j.1600-079x.2006.00407.x.; Kobayashi K, Yamamoto T, Taguchi M, Chiba K. High-performance liquid chromatography determination of N- and O-demethylase activities of chemicals in human liver microsomes: application of postcolumn fluorescence derivatization using Nash reagent. Anal Biochem. 2000 Sep 10;284(2):342–7. doi: 10.1006/abio.2000.4709. PMID: 10964418. |