Pathways Knowlegdes
Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit
| Pathway | DOIs | Note |
|---|---|---|
| soybean saponin I biosynthesis Accession ID: BioCyc:META_PWY-5203 |
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Shibuya M, Nishimura K, Yasuyama N, Ebizuka Y. Identification and characterization of glycosyltransferases involved in the biosynthesis of soyasaponin I in Glycine max. FEBS Lett. 2010 Jun 03;584(11):2258–64. doi: 10.1016/j.febslet.2010.03.037. PMID: 20350545.; Shibuya M, Hoshino M, Katsube Y, Hayashi H, Kushiro T, Ebizuka Y. Identification of beta-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay. FEBS J. 2006 Mar;273(5):948–59. doi: 10.1111/j.1742-4658.2006.05120.x. PMID: 16478469.; Kerwin SM. Soy saponins and the anticancer effects of soybeans and soy-based foods. Curr Med Chem Anticancer Agents. 2004 May;4(3):263–72. doi: 10.2174/1568011043352993. PMID: 15134504.; Xu R, Fazio GC, Matsuda SP. On the origins of triterpenoid skeletal diversity. Phytochemistry. 2004 Feb;65(3):261–91. doi: 10.1016/j.phytochem.2003.11.014. PMID: 14751299.; Hayashi H, Huang P, Inoue K. Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Plant Cell Physiol. 2003 Apr;44(4):404–11. doi: 10.1093/pcp/pcg054. PMID: 12721381.; Dixon RA, Sumner LW. Legume natural products: understanding and manipulating complex pathways for human and animal health. Plant Physiol. 2003 Mar;131(3):878–85. PMID: 12644640; PMCID: PMC1540287.; Suzuki H, Achnine L, Xu R, Matsuda SPT, Dixon RA. A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. The Plant Journal. 2002 Dec;32(6):1033–48. doi: 10.1046/j.1365-313x.2002.01497.x.; Hong KJ, Tokunaga S, Kajiuchi T. Evaluation of remediation process with plant-derived biosurfactant for recovery of heavy metals from contaminated soils. Chemosphere. 2002 Oct;49(4):379–87. doi: 10.1016/s0045-6535(02)00321-1. PMID: 12365835.; Kurosawa Y, Takahara H, Shiraiwa M. UDP-glucuronic acid:soyasapogenol glucuronosyltransferase involved in saponin biosynthesis in germinating soybean seeds. Planta. 2002 Aug;215(4):620–9. doi: 10.1007/s00425-002-0781-x. PMID: 12172845.; Huhman DV, Sumner LW. Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer. Phytochemistry. 2002 Feb;59(3):347–60. doi: 10.1016/s0031-9422(01)00432-0. PMID: 11830145.; HAYASHI H, HUANG P, KIRAKOSYAN A, INOUE K, HIRAOKA N, IKESHIRO Y, KUSHIRO T, SHIBUYA M, EBIZUKA Y. Cloning and Characterization of a cDNA Encoding .BETA.-Amyrin Synthase Involved in Glycyrrhizin and Soyasaponin Biosyntheses in Licorice. Biological & Pharmaceutical Bulletin. 2001;24(8):912–6. doi: 10.1248/bpb.24.912.; Haridas V, Higuchi M, Jayatilake GS, Bailey D, Mujoo K, Blake ME, Arntzen CJ, Gutterman JU. Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc. Natl. Acad. Sci. U.S.A. 2001 May 08;98(10):5821–6. doi: 10.1073/pnas.101619098.; Sowmya P, Rajyalakshmi P. Hypocholesterolemic effect of germinated fenugreek seeds in human subjects. Plant Foods Hum Nutr. 1999;53(4):359–65. doi: 10.1023/a:1008021618733. PMID: 10540988.; Oleszek W, Junkuszew M, Stochmal A. Determination and toxicity of saponins from Amaranthus cruentus seeds. J Agric Food Chem. 1999 Sep;47(9):3685–7. doi: 10.1021/jf990182k. PMID: 10552705.; Kushiro T, Shibuya M, Ebizuka Y. Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. Eur J Biochem. 1998 Aug 15;256(1):238–44. doi: 10.1046/j.1432-1327.1998.2560238.x. PMID: 9746369.; Klita PT, Mathison GW, Fenton TW, Hardin RT. Effects of alfalfa root saponins on digestive function in sheep. J Anim Sci. 1996 May;74(5):1144–56. doi: 10.2527/1996.7451144x. PMID: 8726748. |
| avenacin A-1 biosynthesis Accession ID: BioCyc:META_PWY-7473 |
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Geisler K, Hughes RK, Sainsbury F, Lomonossoff GP, Rejzek M, Fairhurst S, Olsen C, Motawia MS, Melton RE, Hemmings AM, Bak S, Osbourn A. Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proc. Natl. Acad. Sci. U.S.A. 2013 Aug 12;110(35). doi: 10.1073/pnas.1309157110.; Kunii M, Kitahama Y, Fukushima EO, Seki H, Muranaka T, Yoshida Y, Aoyama Y. ß-Amyrin Oxidation by Oat CYP51H10 Expressed Heterologously in Yeast Cells: The First Example of CYP51-Dependent Metabolism Other than the 14-Demethylation of Sterol Precursors. Biological & Pharmaceutical Bulletin. 2012;35(5):801–4. doi: 10.1248/bpb.35.801.; Field B, Fiston-Lavier A, Kemen A, Geisler K, Quesneville H, Osbourn AE. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Proc. Natl. Acad. Sci. U.S.A. 2011 Aug 29;108(38):16116–21. doi: 10.1073/pnas.1109273108.; Chu HY, Wegel E, Osbourn A. From hormones to secondary metabolism: the emergence of metabolic gene clusters in plants. The Plant Journal. 2011 Mar 28;66(1):66–79. doi: 10.1111/j.1365-313x.2011.04503.x.; Sawai S, Saito K. Triterpenoid biosynthesis and engineering in plants. Front Plant Sci. 2011;2():25. PMID: 22639586; PMCID: PMC3355669.; Qin B, Eagles J, Mellon FA, Mylona P, Peña-Rodriguez L, Osbourn AE. High throughput screening of mutants of oat that are defective in triterpene synthesis. Phytochemistry. 2010 Aug;71(11-12):1245–52. doi: 10.1016/j.phytochem.2010.05.016.; Wegel E, Koumproglou R, Shaw P, Osbourn A. Cell Type–Specific Chromatin Decondensation of a Metabolic Gene Cluster in Oats . 2009 Dec 29;21(12):3926–36. doi: 10.1105/tpc.109.072124.; Mugford ST, Qi X, Bakht S, Hill L, Wegel E, Hughes RK, Papadopoulou K, Melton R, Philo M, Sainsbury F, Lomonossoff GP, Roy AD, Goss RJM, Osbourn A. A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats . 2009 Aug 14;21(8):2473–84. doi: 10.1105/tpc.109.065870.; Mylona P, Owatworakit A, Papadopoulou K, Jenner H, Qin B, Findlay K, Hill L, Qi X, Bakht S, Melton R, Osbourn A. Sad3 and sad4 are required for saponin biosynthesis and root development in oat. Plant Cell. 2008 Jan;20(1):201–12. PMID: 18203919; PMCID: PMC2254932.; Qi X, Bakht S, Qin B, Leggett M, Hemmings A, Mellon F, Eagles J, Werck-Reichhart D, Schaller H, Lesot A, Melton R, Osbourn A. A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense. Proc Natl Acad Sci U S A. 2006 Dec 05;103(49):18848–53. PMID: 17124172; PMCID: PMC1656972.; Field B, Jordán F, Osbourn A. First encounters--deployment of defence-related natural products by plants. New Phytol. 2006;172(2):193–207. doi: 10.1111/j.1469-8137.2006.01863.x. PMID: 16995908.; Qi X, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A. A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants. Proc. Natl. Acad. Sci. U.S.A. 2004 May 17;101(21):8233–8. doi: 10.1073/pnas.0401301101.; Haralampidis K, Bryan G, Qi X, Papadopoulou K, Bakht S, Melton R, Osbourn A. A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Proc. Natl. Acad. Sci. U.S.A. 2001 Oct 23;98(23):13431–6. doi: 10.1073/pnas.231324698.; Papadopoulou K, Melton RE, Leggett M, Daniels MJ, Osbourn AE. Compromised disease resistance in saponin-deficient plants. Proc. Natl. Acad. Sci. U.S.A. 1999 Oct 26;96(22):12923–8. doi: 10.1073/pnas.96.22.12923.; Bowyer P, Clarke BR, Lunness P, Daniels MJ, Osbourn AE. Host range of a plant pathogenic fungus determined by a saponin detoxifying enzyme. Science. 1995 Jan 20;267(5196):371–4. doi: 10.1126/science.7824933. PMID: 7824933. |
| oleanolate biosynthesis Accession ID: BioCyc:META_PWY-7069 |
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Huang L, Li J, Ye H, Li C, Wang H, Liu B, Zhang Y. Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta. 2012 Nov;236(5):1571–81. doi: 10.1007/s00425-012-1712-0. PMID: 22837051.; Wei J, Liu M, Liu H, Wang H, Wang F, Zhang Y, Han L, Lin X. Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells. J Appl Toxicol. 2013 Aug;33(8):756–65. doi: 10.1002/jat.2725. PMID: 22678527.; Shih W, Yu F, Chang C, Liao M, Wu H, Lin P. Suppression of |
| glycyrrhetinate biosynthesis Accession ID: BioCyc:META_PWY-7066 |
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Seki H, Sawai S, Ohyama K, Mizutani M, Ohnishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, Muranaka T. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell. 2011 Nov;23(11):4112–23. PMID: 22128119; PMCID: PMC3246328.; Ashfaq UA, Masoud MS, Nawaz Z, Riazuddin S. Glycyrrhizin as antiviral agent against Hepatitis C Virus. Journal of Translational Medicine. 2011 Jul 18;9(1):112. doi: 10.1186/1479-5876-9-112.; Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T. Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14204–9. PMID: 18779566; PMCID: PMC2532699.; Negi AS, Kumar JK, Luqman S, Shanker K, Gupta MM, Khanuja SPS. Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads. Medicinal Research Reviews. 2007 Nov 02;28(5):746–72. doi: 10.1002/med.20115.; HE J, AKAO T, NISHINO T, TANI T. The Influence of Commonly Prescribed Synthetic Drugs for Peptic Ulcer on the Pharmacokinetic Fate of Glycyrrhizin from Shaoyao-Gancao-tang. Biological & Pharmaceutical Bulletin. 2001;24(12):1395–9. doi: 10.1248/bpb.24.1395.; Mauricio I, Francischetti B, Monteiro RQ, Guimarães JA. Identification of Glycyrrhizin as a Thrombin Inhibitor. Biochemical and Biophysical Research Communications. 1997 Jun;235(1):259–63. doi: 10.1006/bbrc.1997.6735.; Norman HA, Pillai P, Baker ME. Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. FEBS Lett. 1995 Jul 10;368(1):135–8. doi: 10.1016/0014-5793(95)00627-l. PMID: 7615067.; Takahara T, Watanabe A, Shiraki K. Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. J Hepatol. 1994 Oct;21(4):601–9. doi: 10.1016/s0168-8278(94)80108-8. PMID: 7814808.; Attfield MD, Hewett P. EXACT EXPRESSIONS FOR THE BIAS AND VARIANCE OF ESTIMATORS OF THE MEAN OF A LOGNORMAL DISTRIBUTION. American Industrial Hygiene Association Journal. 1992 Jul;53(7):432–5. doi: 10.1080/15298669291359906. |
| avenacin biosynthesis, initial reactions Accession ID: BioCyc:META_PWY-6115 |
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Mugford ST, Louveau T, Melton R, Qi X, Bakht S, Hill L, Tsurushima T, Honkanen S, Rosser SJ, Lomonossoff GP, Osbourn A. Modularity of Plant Metabolic Gene Clusters: A Trio of Linked Genes That Are Collectively Required for Acylation of Triterpenes in Oat . 2013 Mar 29;25(3):1078–92. doi: 10.1105/tpc.113.110551.; Trojanowska MR, Osbourn AE, Daniels MJ, Threlfall DR. Biosynthesis of avenacins and phytosterols in roots of Avena sativa cv. Image. Phytochemistry. 2000 May;54(2):153–64. doi: 10.1016/s0031-9422(00)00062-5. PMID: 10872206. |
| pentacyclic triterpene biosynthesis Accession ID: BioCyc:META_PWY-7251 |
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Wang Z, Yeats T, Han H, Jetter R. Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids. J Biol Chem. 2010 Sep 24;285(39):29703–12. PMID: 20610397; PMCID: PMC2943309.; Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K. Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae. FEBS J. 2007 Oct;274(19):5028–42. doi: 10.1111/j.1742-4658.2007.06025.x. PMID: 17803686.; Guhling O, Hobl B, Yeats T, Jetter R. Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis. Archives of Biochemistry and Biophysics. 2006 Apr;448(1-2):60–72. doi: 10.1016/j.abb.2005.12.013.; Fazio GC, Xu R, Matsuda SP. Genome mining to identify new plant triterpenoids. J Am Chem Soc. 2004 May 12;126(18):5678–9. doi: 10.1021/ja0318784. PMID: 15125655.; Hayashi H, Huang P, Inoue K, Hiraoka N, Ikeshiro Y, Yazaki K, Tanaka S, Kushiro T, Shibuya M, Ebizuka Y. Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid. European Journal of Biochemistry. 2001 Dec;268(23):6311–7. doi: 10.1046/j.0014-2956.2001.02588.x.; Segura MJR, Meyer MM, Matsuda SPT. Arabidopsis thaliana LUP1 Converts Oxidosqualene to Multiple Triterpene Alcohols and a Triterpene Diol. Org. Lett. 2000 Jul 01;2(15):2257–9. doi: 10.1021/ol006016b.; Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y. Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase. Eur J Biochem. 2000 Jun;267(12):3453–60. doi: 10.1046/j.1432-1327.2000.01357.x. PMID: 10848960.; Herrera JB, Bartel B, Wilson WK, Matsuda SP. Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Phytochemistry. 1998 Dec;49(7):1905–11. doi: 10.1016/s0031-9422(98)00366-5. PMID: 9883589. |
| mangrove triterpenoid biosynthesis Accession ID: BioCyc:META_PWY-6109 |
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Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K. Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae. FEBS J. 2007 Oct;274(19):5028–42. doi: 10.1111/j.1742-4658.2007.06025.x. PMID: 17803686.; Guhling O, Hobl B, Yeats T, Jetter R. Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis. Archives of Biochemistry and Biophysics. 2006 Apr;448(1-2):60–72. doi: 10.1016/j.abb.2005.12.013.; Segura MJR, Meyer MM, Matsuda SPT. Arabidopsis thaliana LUP1 Converts Oxidosqualene to Multiple Triterpene Alcohols and a Triterpene Diol. Org. Lett. 2000 Jul 01;2(15):2257–9. doi: 10.1021/ol006016b.; Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y. Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase. Eur J Biochem. 2000 Jun;267(12):3453–60. doi: 10.1046/j.1432-1327.2000.01357.x. PMID: 10848960.; Herrera JB, Bartel B, Wilson WK, Matsuda SP. Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Phytochemistry. 1998 Dec;49(7):1905–11. doi: 10.1016/s0031-9422(98)00366-5. PMID: 9883589. |
| ginsenosides biosynthesis Accession ID: BioCyc:META_PWY-5672 |
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Han JY, Kim HJ, Kwon YS, Choi YE. The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 2011 Dec;52(12):2062–73. doi: 10.1093/pcp/pcr150. PMID: 22039120.; Fukushima EO, Seki H, Ohyama K, Ono E, Umemoto N, Mizutani M, Saito K, Muranaka T. CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant Cell Physiol. 2011 Dec;52(12):2050–61. doi: 10.1093/pcp/pcr146. PMID: 22039103.; Tansakul P, Shibuya M, Kushiro T, Ebizuka Y. Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Lett. 2006 Oct 02;580(22):5143–9. doi: 10.1016/j.febslet.2006.08.044. PMID: 16962103.; Mudryi IV. [Agricultural use of fertilizers: ecological and hygienic aspects]. Gig Sanit. 2006 Jul;(4):40–3. PMID: 17078293.; Zhang C, Yu H, Bao Y, An L, Jin F. Purification and characterization of ginsenoside-beta-glucosidase from ginseng. Chem Pharm Bull (Tokyo). 2001 Jul;49(7):795–8. doi: 10.1248/cpb.49.795. PMID: 11456082. |
| superpathway of avenacin A biosynthesis Accession ID: BioCyc:META_PWY-7476 |
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Geisler K, Hughes RK, Sainsbury F, Lomonossoff GP, Rejzek M, Fairhurst S, Olsen C, Motawia MS, Melton RE, Hemmings AM, Bak S, Osbourn A. Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proc. Natl. Acad. Sci. U.S.A. 2013 Aug 12;110(35). doi: 10.1073/pnas.1309157110.; Mugford ST, Louveau T, Melton R, Qi X, Bakht S, Hill L, Tsurushima T, Honkanen S, Rosser SJ, Lomonossoff GP, Osbourn A. Modularity of Plant Metabolic Gene Clusters: A Trio of Linked Genes That Are Collectively Required for Acylation of Triterpenes in Oat . 2013 Mar 29;25(3):1078–92. doi: 10.1105/tpc.113.110551.; Owatworakit A, Townsend B, Louveau T, Jenner H, Rejzek M, Hughes RK, Saalbach G, Qi X, Bakht S, Roy AD, Mugford ST, Goss RJM, Field RA, Osbourn A. Glycosyltransferases from Oat (Avena) Implicated in the Acylation of Avenacins. Journal of Biological Chemistry. 2013 Feb;288(6):3696–704. doi: 10.1074/jbc.m112.426155.; Kunii M, Kitahama Y, Fukushima EO, Seki H, Muranaka T, Yoshida Y, Aoyama Y. ß-Amyrin Oxidation by Oat CYP51H10 Expressed Heterologously in Yeast Cells: The First Example of CYP51-Dependent Metabolism Other than the 14-Demethylation of Sterol Precursors. Biological & Pharmaceutical Bulletin. 2012;35(5):801–4. doi: 10.1248/bpb.35.801.; Field B, Fiston-Lavier A, Kemen A, Geisler K, Quesneville H, Osbourn AE. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Proc. Natl. Acad. Sci. U.S.A. 2011 Aug 29;108(38):16116–21. doi: 10.1073/pnas.1109273108.; Chu HY, Wegel E, Osbourn A. From hormones to secondary metabolism: the emergence of metabolic gene clusters in plants. The Plant Journal. 2011 Mar 28;66(1):66–79. doi: 10.1111/j.1365-313x.2011.04503.x.; Podolak I, Galanty A, Sobolewska D. Saponins as cytotoxic agents: a review. Phytochemistry Reviews. 2010 Jun 25;9(3):425–74. doi: 10.1007/s11101-010-9183-z.; Wegel E, Koumproglou R, Shaw P, Osbourn A. Cell Type–Specific Chromatin Decondensation of a Metabolic Gene Cluster in Oats . 2009 Dec 29;21(12):3926–36. doi: 10.1105/tpc.109.072124.; Mugford ST, Qi X, Bakht S, Hill L, Wegel E, Hughes RK, Papadopoulou K, Melton R, Philo M, Sainsbury F, Lomonossoff GP, Roy AD, Goss RJM, Osbourn A. A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats . 2009 Aug 14;21(8):2473–84. doi: 10.1105/tpc.109.065870.; Mylona P, Owatworakit A, Papadopoulou K, Jenner H, Qin B, Findlay K, Hill L, Qi X, Bakht S, Melton R, Osbourn A. Sad3 and sad4 are required for saponin biosynthesis and root development in oat. Plant Cell. 2008 Jan;20(1):201–12. PMID: 18203919; PMCID: PMC2254932.; Qi X, Bakht S, Qin B, Leggett M, Hemmings A, Mellon F, Eagles J, Werck-Reichhart D, Schaller H, Lesot A, Melton R, Osbourn A. A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense. Proc Natl Acad Sci U S A. 2006 Dec 05;103(49):18848–53. PMID: 17124172; PMCID: PMC1656972.; Field B, Jordán F, Osbourn A. First encounters--deployment of defence-related natural products by plants. New Phytol. 2006;172(2):193–207. doi: 10.1111/j.1469-8137.2006.01863.x. PMID: 16995908.; Qi X, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A. A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants. Proc. Natl. Acad. Sci. U.S.A. 2004 May 17;101(21):8233–8. doi: 10.1073/pnas.0401301101.; Quiel JA, Bender J. Glucose Conjugation of Anthranilate by theArabidopsis UGT74F2 Glucosyltransferase Is Required for Tryptophan Mutant Blue Fluorescence. Journal of Biological Chemistry. 2003 Feb;278(8):6275–81. doi: 10.1074/jbc.m211822200.; Haralampidis K, Bryan G, Qi X, Papadopoulou K, Bakht S, Melton R, Osbourn A. A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Proc. Natl. Acad. Sci. U.S.A. 2001 Oct 23;98(23):13431–6. doi: 10.1073/pnas.231324698.; Papadopoulou K, Melton RE, Leggett M, Daniels MJ, Osbourn AE. Compromised disease resistance in saponin-deficient plants. Proc. Natl. Acad. Sci. U.S.A. 1999 Oct 26;96(22):12923–8. doi: 10.1073/pnas.96.22.12923.; Bowyer P, Clarke BR, Lunness P, Daniels MJ, Osbourn AE. Host range of a plant pathogenic fungus determined by a saponin detoxifying enzyme. Science. 1995 Jan 20;267(5196):371–4. doi: 10.1126/science.7824933. PMID: 7824933. |
| soybean saponin I biosynthesis Accession ID: PlantCyc:BANANA_PWY-5203 |
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| avenacin biosynthesis, initial reactions Accession ID: PlantCyc:PHALLII_PWY-6115 |
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| soybean saponin I biosynthesis Accession ID: PlantCyc:FLAX_PWY-5203 |
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| mangrove triterpenoid biosynthesis Accession ID: PlantCyc:SWEETORANGE_PWY-6109 |
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| ginsenosides biosynthesis Accession ID: PlantCyc:CARROT_PWY-5672 |
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| mangrove triterpenoid biosynthesis Accession ID: PlantCyc:FVESCA_VESCA_PWY-6109 |
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| mangrove triterpenoid biosynthesis Accession ID: PlantCyc:GRAIMONDII_PWY-6109 |
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| mangrove triterpenoid biosynthesis Accession ID: PlantCyc:HOP_PWY-6109 |
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| soybean saponin I biosynthesis Accession ID: PlantCyc:POPLAR_PWY-5203 |
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