ceramide biosynthesis

Cuvillier O. Sphingosine in apoptosis signaling. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2002 Dec;1585(2-3):153–62. doi: 10.1016/s1388-1981(02)00336-0.; Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000 Feb;10(2):73–80. doi: 10.1016/s0962-8924(99)01694-3. PMID: 10652518.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Dihydroceramide

Formula: C19H39NO3 (329.29297840000004)

CAS ID:

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.3.1.-
1.1.1.102 3-dehydrosphinganine reductase D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase
1.14.18.5 sphingolipid C4-monooxygenase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
1.14.19.17 sphingolipid 4-desaturase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
2.3.1.24 sphingosine N-acyltransferase acyl-CoA:sphingosine N-acyltransferase
2.3.1.291 sphingoid base N-palmitoyltransferase palmitoyl-CoA:sphingoid base N-palmitoyltransferase
2.3.1.297 very-long-chain ceramide synthase very-long-chain fatty acyl-coA:sphingoid base N-acyltransferase
2.3.1.299 sphingoid base N-stearoyltransferase stearoyl-CoA:sphingoid base N-stearoyltransferase
2.3.1.50 serine C-palmitoyltransferase palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)


Proteins

Protein ID name full name