4-methyl-5(β-hydroxyethyl)thiazole salvage

Jurgenson CT, Begley TP, Ealick SE. The Structural and Biochemical Foundations of Thiamin Biosynthesis. Annu. Rev. Biochem. 2009 Jun 01;78(1):569–603. doi: 10.1146/annurev.biochem.78.072407.102340.; Kowalska E, Kozik A. The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts. Cellular & Molecular Biology Letters. 2008 Apr 10;13(2):271–82. doi: 10.2478/s11658-007-0055-5.; Nosaka K, Nishimura H, Kawasaki Y, Tsujihara T, Iwashima A. Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. Journal of Biological Chemistry. 1994 Dec;269(48):30510–6. doi: 10.1016/s0021-9258(18)43843-4.

Metabolites

5-(2-Hydroxyethyl)-4-methylthiazole

Formula: C6H9NOS (143.0404824)

CAS ID: 137-00-8

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

thiamine(1+) monophosphate(2-)

Formula: C12H16N4O4PS (343.06298460000005)

CAS ID: 532-40-1



Enzyme

EC Number name full name note
2.5.1.3 thiamine phosphate synthase 4-amino-2-methyl-5-diphosphomethylpyrimidine:2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate 4-amino-2-methylpyrimidine-5-methenyltransferase (decarboxylating)
2.7.1.50 hydroxyethylthiazole kinase ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase


Proteins

Protein ID name full name
P41835 THI6 Thiamine biosynthetic bifunctional enzyme