superpathway of leucine, valine, and isoleucine biosynthesis

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-aceto-2-hydroxy-butanoate

Formula: C6H9O4 (145.0500814)

CAS ID:

2-isopropylmalate(2-)

Formula: C7H10O5 (174.052821)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

3-methyl-2-oxobutanoate

Formula: C5H7O3 (115.0395172)

CAS ID:

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

2-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:

4-methyl-2-oxopentanoate

Formula: C6H9O3 (129.05516640000002)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.2.1.6 acetolactate synthase pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
4.2.1.33 3-isopropylmalate dehydratase (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
4.2.1.9 dihydroxy-acid dehydratase 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming)


Proteins

Protein ID name full name
P0A6A7 leuC 3-isopropylmalate dehydratase large subunit
P0AB81 ilvE Branched-chain-amino-acid aminotransferase
P0ADF9 ilvN Acetolactate synthase isozyme 1 small subunit
P0ADG2 ilvM Acetolactate synthase isozyme 2 small subunit
Q8FBR5 ilvD Dihydroxy-acid dehydratase
Q8FL79 leuD 3-isopropylmalate dehydratase small subunit