L-ornithine degradation II (Stickland reaction)
Kenklies J, Ziehn R, Fritsche K, Pich A, Andreesen JR. Proline biosynthesis from L-ornithine in Clostridium sticklandii: purification of delta1-pyrroline-5-carboxylate reductase, and sequence and expression of the encoding gene, proC. Microbiology (Reading). 1999 Apr;145 ( Pt 4)():819–26. doi: 10.1099/13500872-145-4-819. PMID: 10220161.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.21.4.1 | D-proline reductase | 5-aminopentanoate:[PrdC protein] oxidoreductase (cyclizing) | |
| 1.4.1.26 | 2,4-diaminopentanoate dehydrogenase (NAD+) | (2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating) | |
| 2.3.1.263 | 2-amino-4-oxopentanoate thiolase | acetyl-CoA:D-alanine acetyltransferase | |
| 5.1.1.12 | ornithine racemase | ornithine racemase | |
| 5.4.3.5 | D-ornithine 4,5-aminomutase | D-ornithine 4,5-aminomutase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| C1FW05 | ord | 2,4-diaminopentanoate dehydrogenase |
| C1FW06 | ortA | 2-amino-4-ketopentanoate thiolase alpha subunit |
| C1FW07 | ortB | 2-amino-4-ketopentanoate thiolase beta subunit |
| C1FW08 | orr | Ornithine racemase |
| E3PY95 | oraE | D-ornithine 4,5-aminomutase subunit beta |
| E3PY96 | oraS | D-ornithine 4,5-aminomutase subunit alpha |
| Q9Z4P6 | prdA | D-proline reductase proprotein PrdA |
| Q9Z4Q7 | prdB | D-proline reductase subunit gamma |