xanthine and xanthosine salvage

Stoychev G, Kierdaszuk B, Shugar D. Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems. Eur J Biochem. 2002 Aug;269(16):4048–57. doi: 10.1046/j.1432-1033.2002.03097.x. PMID: 12180982.; Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349–425. doi: 10.1016/s0163-7258(00)00097-8. PMID: 11337031.; Seeger C, Poulsen C, Dandanell G. Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli. J Bacteriol. 1995 Oct;177(19):5506–16. doi: 10.1128/jb.177.19.5506-5516.1995.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Xanthine

Formula: C5H4N4O2 (152.0334244)

CAS ID: 69-89-6

Xanthosine

Formula: C10H12N4O6 (284.07568119999996)

CAS ID: 146-80-5

8-Azaguanine

Formula: C4H4N6O (152.0446574)

CAS ID: 134-58-7



Enzyme

EC Number name full name note
2.4.2.-
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.4.2.2 pyrimidine-nucleoside phosphorylase pyrimidine-nucleoside:phosphate (2'-deoxy)-alpha-D-ribosyltransferase
2.4.2.22 xanthine phosphoribosyltransferase XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase


Proteins

Protein ID name full name
P0A9M5 gpt Xanthine-guanine phosphoribosyltransferase
P0C037 ppnP Pyrimidine/purine nucleoside phosphorylase
P45563 xapA Purine nucleoside phosphorylase 2