albaflavenone biosynthesis

Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE. Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 2008 Mar;283(13):8183–9. doi: 10.1074/jbc.m710421200.

Metabolites

(+)-epi-Isozizaene

Formula: C15H24 (204.18779039999998)

CAS ID:

(5R)-Albaflavenol

Formula: C15H24O (220.18270539999997)

CAS ID:

(5S)-Albaflavenol

Formula: C15H24O (220.18270539999997)

CAS ID:

Albaflavenone

Formula: C15H22O (218.1670562)

CAS ID: 159344-56-6

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.14.15.39 epi-isozizaene 5-monooxygenase (+)-epi-isozizaene,reduced-ferredoxin:oxygen oxidoreductase (5-hydroxylating)
4.2.3.37 epi-isozizaene synthase (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]
4.2.3.47 beta-farnesene synthase (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-beta-farnesene-forming]


Proteins

Protein ID name full name
Q9K498 EIZFM_STRCO Bifunctional albaflavenone monooxygenase/terpene synthase
Q9K499 cyc1 Epi-isozizaene synthase