L-leucine biosynthesis

Vartak NB, Liu L, Wang BM, Berg CM. A functional leuABCD operon is required for leucine synthesis by the tyrosine-repressible transaminase in Escherichia coli K-12. J Bacteriol. 1991 Jun;173(12):3864–71. doi: 10.1128/jb.173.12.3864-3871.1991.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

3-methyl-2-oxobutanoate

Formula: C5H7O3 (115.0395172)

CAS ID:

4-methyl-2-oxopentanoate

Formula: C6H9O3 (129.05516640000002)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
2.3.3.13 2-isopropylmalate synthase acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2.6.1.107 beta-methylphenylalanine transaminase (2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
2.6.1.57 aromatic-amino-acid transaminase aromatic-amino-acid:2-oxoglutarate aminotransferase


Proteins

Protein ID name full name
P04693 tyrB Aromatic-amino-acid aminotransferase
P09151 leuA 2-isopropylmalate synthase
P0AB80 ilvE Branched-chain-amino-acid aminotransferase