L-leucine degradation III

Dickinson JR, Lanterman MM, Danner DJ, Pearson BM, Sanz P, Harrison SJ, Hewlins MJE. A 13C Nuclear Magnetic Resonance Investigation of the Metabolism of Leucine to Isoamyl Alcohol in Saccharomyces cerevisiae. Journal of Biological Chemistry. 1997 Oct;272(43):26871–8. doi: 10.1074/jbc.272.43.26871.

Metabolites

3-Methylbutanal

Formula: C5H10O (86.07316100000001)

CAS ID: 590-86-3

3-Methylbutanol

Formula: C5H12O (88.0888102)

CAS ID: 123-51-3

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

4-methyl-2-oxopentanoate

Formula: C6H9O3 (129.05516640000002)

CAS ID:

thiamine(1+) diphosphate(3-)

Formula: C12H16N4O7P2S (422.0214926)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.1 alcohol dehydrogenase alcohol:NAD+ oxidoreductase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
1.1.1.54 allyl-alcohol dehydrogenase allyl-alcohol:NADP+ oxidoreductase
1.1.1.78 methylglyoxal reductase (NADH) (R)-lactaldehyde:NAD+ oxidoreductase
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
4.1.1.72 branched-chain-2-oxoacid decarboxylase (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)


Proteins

Protein ID name full name
P00330 ADH1 Alcohol dehydrogenase 1
P00331 ADH2 Alcohol dehydrogenase 2
P07246 ADH3 Alcohol dehydrogenase 3, mitochondrial
P10127 ADH4 Alcohol dehydrogenase 4
P32771 SFA1 S-(hydroxymethyl)glutathione dehydrogenase
P38113 ADH5 Alcohol dehydrogenase 5
P38891 BAT1 Branched-chain-amino-acid aminotransferase, mitochondrial
Q07471 THI3 Thiamine metabolism regulatory protein THI3