6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
Basset G, Quinlivan EP, Ziemak MJ, Diaz De La Garza R, Fischer M, Schiffmann S, Bacher A, Gregory JF, Hanson AD. Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12489–94. PMID: 12221287; PMCID: PMC129472.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.6.1.- | |||
| 2.7.6.3 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase | |
| 3.5.4.16 | GTP cyclohydrolase I | GTP 7,8-8,9-dihydrolase | |
| 3.6.1.22 | NAD+ diphosphatase | NAD+ phosphohydrolase | |
| 3.6.1.55 | 8-oxo-dGTP diphosphatase | 8-oxo-dGTP diphosphohydrolase | |
| 3.6.1.67 | dihydroneopterin triphosphate diphosphatase | 7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase | |
| 4.1.2.25 | dihydroneopterin aldolase | 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming] | |
| 5.1.99.8 | 7,8-dihydroneopterin epimerase | 7,8-dihydroneopterin 2'-epimerase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P0A6T5 | folE | GTP cyclohydrolase 1 |
| P0AC16 | folB | Dihydroneopterin aldolase |
| P0AFC0 | nudB | Dihydroneopterin triphosphate diphosphatase |
| P26281 | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
| Q9CGE1 | ylgG | hypothetical protein |