ceramide de novo biosynthesis

Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012 Feb 01;441(3):789–802. PMID: 22248339; PMCID: PMC3689921.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Dihydroceramide

Formula: C19H39NO3 (329.29297840000004)

CAS ID:

3-dehydrosphinganinium(1+)

Formula: C18H38NO2 (300.2902388)

CAS ID:

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
5.2.1.-
1.1.1.102 3-dehydrosphinganine reductase D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase
1.14.19.17 sphingolipid 4-desaturase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
2.3.1.299 sphingoid base N-stearoyltransferase stearoyl-CoA:sphingoid base N-stearoyltransferase
2.3.1.50 serine C-palmitoyltransferase palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)


Proteins

Protein ID name full name