superpathway of menaquinol-8 biosynthesis II

Li X, Apel D, Gaynor EC, Tanner ME. 5'-Methylthioadenosine Nucleosidase Is Implicated in Playing a Key Role in a Modified Futalosine Pathway for Menaquinone Biosynthesis in Campylobacter jejuni. Journal of Biological Chemistry. 2011 Jun;286(22):19392–8. doi: 10.1074/jbc.m111.229781.; HIRATSUKA T, ITOH N, SETO H, DAIRI T. Enzymatic Properties of Futalosine Hydrolase, an Enzyme Essential to a Newly Identified Menaquinone Biosynthetic Pathway. Bioscience, Biotechnology, and Biochemistry. 2009 May 23;73(5):1137–41. doi: 10.1271/bbb.80906.; Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T. An alternative menaquinone biosynthetic pathway operating in microorganisms. Science. 2008 Sep 19;321(5896):1670–3. doi: 10.1126/science.1160446. PMID: 18801996.; Heide L, Leistner E. Enzymatic synthesis of the coenzyme a ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis. FEBS Letters. 1981 Jun 15;128(2):201–4. doi: 10.1016/0014-5793(81)80080-4.

Metabolites

5'-Deoxyadenosine

Formula: C10H13N5O3 (251.10183480000003)

CAS ID: 4754-39-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Hypoxanthine

Formula: C5H4N4O (136.03850939999998)

CAS ID: 68-94-0



Enzyme

EC Number name full name note
1.21.98.1 cyclic dehypoxanthinyl futalosine synthase dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing)
2.5.1.120 aminodeoxyfutalosine synthase S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming)
3.2.2.26 futalosine hydrolase futalosine ribohydrolase
4.1.99.29 5,8-dihydroxy-2-naphthoate synthase cyclic dehypoxanthine futalosine lyase (dihydroxyacetone-forming)
4.2.1.151 chorismate dehydratase chorismate hydro-lyase (3-[(1-carboxyvinyl)oxy]benzoate-forming)


Proteins

Protein ID name full name
Q5SK48 mqnE Aminodeoxyfutalosine synthase
Q5SKT7 mqnB Futalosine hydrolase
Q9KXN1 mqnD 1,4-dihydroxy-6-naphtoate synthase
Q9L0T8 mqnA Chorismate dehydratase
Q9XAP2 mqnC Cyclic dehypoxanthine futalosine synthase