cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate
Di´az E, Ferra´ndez A, Garci´a JL. Characterization of the hca Cluster Encoding the Dioxygenolytic Pathway for Initial Catabolism of 3-Phenylpropionic Acid in Escherichia coli K-12. J Bacteriol. 1998 Jun;180(11):2915–23. doi: 10.1128/jb.180.11.2915-2923.1998.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.13.11.16 | 3-carboxyethylcatechol 2,3-dioxygenase | 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing) | |
| 1.14.12.19 | 3-phenylpropanoate dioxygenase | 3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) | |
| 1.14.13.127 | 3-(3-hydroxyphenyl)propanoate hydroxylase | 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating) | |
| 1.18.1.3 | ferredoxin-NAD+ reductase | ferredoxin:NAD+ oxidoreductase | |
| 1.3.1.87 | 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase | 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase | |
| 3.7.1.14 | 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase | (2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P0ABR5 | hcaE | 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha |
| P0ABR9 | mhpB | 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase |
| P0CI31 | hcaB | 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase |
| P77044 | mhpC | 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase |
| P77397 | mhpA | 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase |
| P77650 | hcaD | 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component |
| Q47140 | hcaF | 3-phenylpropionate/cinnamic acid dioxygenase subunit beta |