myo-, chiro- and scyllo-inositol degradation

Morinaga T, Ashida H, Yoshida KI. Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis. Microbiology (Reading). 2010 May;156(Pt 5):1538–46. doi: 10.1099/mic.0.037499-0. PMID: 20133360.; Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y. myo-Inositol Catabolism in Bacillus subtilis. Journal of Biological Chemistry. 2008 Apr;283(16):10415–24. doi: 10.1074/jbc.m708043200.; Yoshida K, Yamaguchi M, Morinaga T, Ikeuchi M, Kinehara M, Ashida H. Genetic Modification of Bacillus subtilis for Production of d - chiro -Inositol, an Investigational Drug Candidate for Treatment of Type 2 Diabetes and Polycystic Ovary Syndrome. Appl Environ Microbiol. 2006 Feb;72(2):1310–5. doi: 10.1128/aem.72.2.1310-1315.2006.; Zhang R-, Dementieva I, Duke N, Collart F, Quaite-Randall E, Alkire R, Dieckman L, Maltsev N, Korolev O, Joachimiak A. Crystal structure of Bacillus subtilis ioli shows endonuclase IV fold with altered Zn binding. Proteins. 2002 Jun 05;48(2):423–6. doi: 10.1002/prot.10159.; Ramaley R, Fujita Y, Freese E. Purification and properties of Bacillus subtilis inositol dehydrogenase. Journal of Biological Chemistry. 1979 Aug;254(16):7684–90. doi: 10.1016/s0021-9258(18)36000-9.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

myo-Inositol

Formula: C6H12O6 (180.0633852)

CAS ID: 87-89-8

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.18 inositol 2-dehydrogenase myo-inositol:NAD+ 2-oxidoreductase
1.1.1.369 D-chiro-inositol 1-dehydrogenase 1D-chiro-inositol:NAD+ 1-oxidoreductase
1.1.1.370 scyllo-inositol 2-dehydrogenase (NAD+) scyllo-inositol:NAD+ 2-oxidoreductase
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating) 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
2.7.1.92 5-dehydro-2-deoxygluconokinase ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase
3.7.1.22 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening) D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (ring-opening)
4.1.2.29 5-dehydro-2-deoxyphosphogluconate aldolase 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (glycerone-phosphate-forming)
4.2.1.44 myo-inosose-2 dehydratase 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)
5.3.1.30 5-deoxy-glucuronate isomerase 5-deoxy-D-glucuronate aldose-ketose-isomerase
5.3.99.11 2-keto-myo-inositol isomerase 2,4,6/3,5-pentahydroxycyclohexanone 2-isomerase


Proteins

Protein ID name full name
P26935 iolG Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
P40332 iolX scyllo-inositol 2-dehydrogenase (NAD(+))
P42412 iolA Malonate-semialdehyde dehydrogenase
P42413 iolB 5-deoxy-glucuronate isomerase
P42414 iolC 5-dehydro-2-deoxygluconokinase
P42415 iolD 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase
P42416 iolE Inosose dehydratase
P42419 iolI Inosose isomerase
P42420 iolJ 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase