superpathway of acetyl-CoA biosynthesis

Tovar-Méndez A, Miernyk JA, Randall DD. Regulation of pyruvate dehydrogenase complex activity in plant cells. European Journal of Biochemistry. 2003 Mar;270(6):1043–9. doi: 10.1046/j.1432-1033.2003.03469.x.; Fatland BL, Ke J, Anderson MD, Mentzen WI, Cui LW, Allred CC, Johnston JL, Nikolau BJ, Wurtele ES. Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis. Plant Physiol. 2002 Oct;130(2):740–56. PMID: 12376641; PMCID: PMC166603.; Nikolau BJ, Oliver DJ, Schnable PS, Wurtele ES. Molecular biology of acetyl-CoA metabolism. Biochem. Soc. Trans. 2000 Dec 01;28(6):591. doi: 10.1042/0300-5127:0280591.; Fatland B, Anderson M, Nikolau BJ, Wurtele ES. Molecular biology of cytosolic acetyl-CoA generation. Biochem. Soc. Trans. 2000 Dec 01;28(6):593. doi: 10.1042/0300-5127:0280593.; Mooney BP, Miernyk JA, Randall DD. Cloning and characterization of the dihydrolipoamide S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) from Arabidopsis. Plant Physiol. 1999 Jun;120(2):443–52. PMID: 10364395; PMCID: PMC59282.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

oxaloacetate(2-)

Formula: C4H2O5 (129.9902242)

CAS ID: 149-63-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

citrate(3-)

Formula: C6H5O7 (189.00352800000002)

CAS ID: 126-44-3

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.12 dihydrolipoyllysine-residue acetyltransferase acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase


Proteins

Protein ID name full name