guanine and guanosine salvage

Xu Y, Eads J, Sacchettini JC, Grubmeyer C. Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry. Biochemistry. 1997 Mar 25;36(12):3700–12. doi: 10.1021/bi9616007. PMID: 9132023.; Liu SW, Milman G. Purification and characterization of Escherichia coli guanine-xanthine phosphoribosyltransferase produced by a high efficiency expression plasmid utilizing a lambda PL promoter and CI857 temperature-sensitive repressor. Journal of Biological Chemistry. 1983 Jun;258(12):7469–75. doi: 10.1016/s0021-9258(18)32201-4.; Lewis AS, Lowy BA. Human erythrocyte purine nucleoside phosphorylase: molecular weight and physical properties. A Theorell-Chance catalytic mechanism. Journal of Biological Chemistry. 1979 Oct;254(19):9927–32. doi: 10.1016/s0021-9258(19)83606-2.; Hammer-Jespersen K, Munch-Petersen A, Nygaard P, Schwartz M. Induction of Enzymes Involved in the Catabolism of Deoxyribonucleosides and Ribonucleosides in Escherichia coli K 12. European Journal of Biochemistry. 1971 Apr;19(4):533–8. doi: 10.1111/j.1432-1033.1971.tb01345.x.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Guanine

Formula: C5H5N5O (151.049408)

CAS ID: 73-40-5

Guanosine

Formula: C10H13N5O5 (283.09166480000005)

CAS ID: 118-00-3

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0



Enzyme

EC Number name full name note
2.4.2.-
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.4.2.2 pyrimidine-nucleoside phosphorylase pyrimidine-nucleoside:phosphate (2'-deoxy)-alpha-D-ribosyltransferase
2.4.2.22 xanthine phosphoribosyltransferase XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase IMP:diphosphate phospho-D-ribosyltransferase


Proteins

Protein ID name full name
P0A9M2 hpt Hypoxanthine phosphoribosyltransferase
P0A9M5 gpt Xanthine-guanine phosphoribosyltransferase
P0ABP8 deoD Purine nucleoside phosphorylase DeoD-type
P0C037 ppnP Pyrimidine/purine nucleoside phosphorylase
P45563 xapA Purine nucleoside phosphorylase 2