enterobacterial common antigen biosynthesis

Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ. Accumulation of the Enterobacterial Common Antigen Lipid II Biosynthetic Intermediate Stimulates degP Transcription in Escherichia coli. J Bacteriol. 1998 Nov 15;180(22):5875–84. doi: 10.1128/jb.180.22.5875-5884.1998.

Metabolites

3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate

Formula: C32H58N2O7S (614.3964518)

CAS ID: 75621-03-3

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

dTDP-alpha-D-glucose

Formula: C16H24N2O16P2 (562.0601044)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

dTDP(3-)

Formula: C10H13N2O11P2 (398.9994588)

CAS ID:

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.336 UDP-N-acetyl-D-mannosamine dehydrogenase UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
2.3.1.210 dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-galactose N-acetyltransferase
2.4.1.180 lipopolysaccharide N-acetylmannosaminouronosyltransferase UDP-N-acetyl-beta-D-mannosaminouronate:lipid I N-acetyl-beta-D-mannosaminouronosyltransferase
2.4.1.325 TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase TDP-N-acetyl-alpha-D-fucose:N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol N-acetylfucosaminyltransferase
2.6.1.59 dTDP-4-amino-4,6-dideoxygalactose transaminase dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase
2.7.7.24 glucose-1-phosphate thymidylyltransferase dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase
2.7.8.33 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase
4.2.1.46 dTDP-glucose 4,6-dehydratase dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)
5.1.3.14 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) UDP-N-acetyl-alpha-D-glucosamine 2-epimerase


Proteins

Protein ID name full name
P0AC78 wecA Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
P27828 wecB UDP-N-acetylglucosamine 2-epimerase
P27829 wecC UDP-N-acetyl-D-mannosamine dehydrogenase
P27830 rffG dTDP-glucose 4,6-dehydratase 2
P27832 wecD dTDP-fucosamine acetyltransferase
P27833 wecE dTDP-4-amino-4,6-dideoxygalactose transaminase
P27836 wecG UDP-N-acetyl-D-mannosaminuronic acid transferase
P37744 rfbA Glucose-1-phosphate thymidylyltransferase 1
P56258 wecF TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase
P61887 rffH Glucose-1-phosphate thymidylyltransferase 2