L-isoleucine degradation II
Dickinson JR, Harrison SJ, Dickinson JA, Hewlins MJE. An Investigation of the Metabolism of Isoleucine to Active Amyl Alcohol in Saccharomyces cerevisiae. Journal of Biological Chemistry. 2000 Apr;275(15):10937–42. doi: 10.1074/jbc.275.15.10937.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.- | |||
| 1.1.1.1 | alcohol dehydrogenase | alcohol:NAD+ oxidoreductase | |
| 1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase | S-(hydroxymethyl)glutathione:NAD+ oxidoreductase | |
| 1.1.1.54 | allyl-alcohol dehydrogenase | allyl-alcohol:NADP+ oxidoreductase | |
| 1.1.1.78 | methylglyoxal reductase (NADH) | (R)-lactaldehyde:NAD+ oxidoreductase | |
| 2.6.1.42 | branched-chain-amino-acid transaminase | branched-chain-amino-acid:2-oxoglutarate aminotransferase | |
| 4.1.1.43 | phenylpyruvate decarboxylase | phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming) | |
| 4.1.1.72 | branched-chain-2-oxoacid decarboxylase | (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming) | |
| 4.1.1.74 | indolepyruvate decarboxylase | 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming] | |
| 4.1.1.80 | 4-hydroxyphenylpyruvate decarboxylase | 4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00330 | ADH1 | Alcohol dehydrogenase 1 |
| P00331 | ADH2 | Alcohol dehydrogenase 2 |
| P06169 | PDC1 | Pyruvate decarboxylase isozyme 1 |
| P07246 | ADH3 | Alcohol dehydrogenase 3, mitochondrial |
| P10127 | ADH4 | Alcohol dehydrogenase 4 |
| P16467 | PDC5 | Pyruvate decarboxylase isozyme 2 |
| P26263 | PDC6 | Pyruvate decarboxylase isozyme 3 |
| P32771 | SFA1 | S-(hydroxymethyl)glutathione dehydrogenase |
| P38113 | ADH5 | Alcohol dehydrogenase 5 |
| P38891 | BAT1 | Branched-chain-amino-acid aminotransferase, mitochondrial |
| Q06408 | ARO10 | Transaminated amino acid decarboxylase |
| Q07471 | THI3 | Thiamine metabolism regulatory protein THI3 |