ergosterol biosynthesis I

Parks LW, Casey WM. Physiological implications of sterol biosynthesis in yeast. Annu Rev Microbiol. 1995;49():95–116. doi: 10.1146/annurev.mi.49.100195.000523. PMID: 8561481.; Zhakovskaia ZA, Mikhailova NP, Kamilova TA, Ogorodnikova TE, V'iunov KA. [Characteristics of the final stages of ergosterol biosynthesis in Saccharomyces cerevisiae yeasts]. Izv Akad Nauk SSSR Biol. 1989 Jan;(1):95–101. PMID: 2654239.; Osumi T, Taketani S, Katsuki H, Kuhara T, Matsumoto I. Ergosterol biosynthesis in yeast. Pathways in the late stages and their variation under various conditions. J Biochem. 1978 Mar;83(3):681–91. doi: 10.1093/oxfordjournals.jbchem.a131961. PMID: 346585.

Metabolites

5-Dehydroepisterol

Formula: C28H44O (396.3391974)

CAS ID: 23582-83-4

CO

Formula: CO (27.994915)

CAS ID: 630-08-0

Ergosta-5,7,22,24(28)-tetraen-3beta-ol

Formula: C28H42O (394.3235482)

CAS ID: 29560-24-5

Ergosterol

Formula: C28H44O (396.3391974)

CAS ID: 57-87-4

Fecosterol

Formula: C28H46O (398.3548466)

CAS ID: 516-86-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zymosterol

Formula: C27H44O (384.3391974)

CAS ID: 128-33-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
5.-.-.-
1.14.19.20 DELTA7-sterol 5(6)-desaturase DELTA7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating
1.14.19.41 sterol 22-desaturase ergosta-5,7,24(28)-trien-3beta-ol,NADPH:oxygen oxidoreductase (22,23-dehydrogenating)
1.3.1.71 DELTA24(241)-sterol reductase ergosterol:NADP+ DELTA24(241)-oxidoreductase
2.1.1.41 sterol 24-C-methyltransferase S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase


Proteins

Protein ID name full name
P25087 ERG6 Sterol 24-C-methyltransferase ERG6
P25340 ERG4 Delta(24(24(1)))-sterol reductase ERG4
P32352 ERG2 C-8 sterol isomerase ERG2
P32353 ERG3 Delta(7)-sterol 5(6)-desaturase ERG3
P54781 ERG5 C-22 sterol desaturase ERG5