inosine-5'-phosphate biosynthesis II

Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ. Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. Arch Biochem Biophys. 1998 Mar 01;351(1):123–34. doi: 10.1006/abbi.1997.0512. PMID: 9500840.; He B, Smith JM, Zalkin H. Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. J Bacteriol. 1992 Jan;174(1):130–6. doi: 10.1128/jb.174.1.130-136.1992.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

Formula: C9H13N4O8P (336.0470988)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase
3.5.4.10 IMP cyclohydrolase IMP 1,2-hydrolase (decyclizing)
4.1.1.21 phosphoribosylaminoimidazole carboxylase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
4.3.2.2 adenylosuccinate lyase N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)


Proteins

Protein ID name full name
P21264 ADE2 Phosphoribosylaminoimidazole carboxylase
P27616 ADE1 Phosphoribosylaminoimidazole-succinocarboxamide synthase
P38009 ADE17 Bifunctional purine biosynthesis protein ADE17
P54113 ADE16 Bifunctional purine biosynthesis protein ADE16
Q05911 ADE13 Adenylosuccinate lyase