geranyl diphosphate biosynthesis

Burke C, Klettke K, Croteau R. Heteromeric geranyl diphosphate synthase from mint: construction of a functional fusion protein and inhibition by bisphosphonate substrate analogs. Archives of Biochemistry and Biophysics. 2004 Feb;422(1):52–60. doi: 10.1016/j.abb.2003.12.003.; Bouvier F, Suire C, d'Harlingue A, Backhaus RA, Camara B. Molecular cloning of geranyl diphosphate synthase and compartmentation of monoterpene synthesis in plant cells. Plant J. 2000 Oct;24(2):241–52. doi: 10.1046/j.1365-313x.2000.00875.x. PMID: 11069698.; Burke CC, Wildung MR, Croteau R. Geranyl diphosphate synthase: Cloning, expression, and characterization of this prenyltransferase as a heterodimer. Proc. Natl. Acad. Sci. U.S.A. 1999 Nov 09;96(23):13062–7. doi: 10.1073/pnas.96.23.13062.

Metabolites



Enzyme

EC Number name full name note
2.5.1.-
2.5.1.1 dimethylallyltranstransferase prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate prenyltranstransferase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
2.5.1.29 geranylgeranyl diphosphate synthase (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
2.5.1.85 all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units)


Proteins

Protein ID name full name
P08524 ERG20 Farnesyl pyrophosphate synthase
P22939 ispA Farnesyl diphosphate synthase
Q53479 idsA Short chain isoprenyl diphosphate synthase