α-tocopherol degradation

Mustacich DJ, Leonard SW, Patel NK, Traber MG. a-tocopherol ß-oxidation localized to rat liver mitochondria. Free Radical Biology and Medicine. 2010 Jan;48(1):73–81. doi: 10.1016/j.freeradbiomed.2009.10.024.; Mustacich DJ, Bruno RS, Traber MG. Vitamin E. Vitam Horm. 2007;76():1–21. doi: 10.1016/s0083-6729(07)76001-6. PMID: 17628169.

Metabolites

alpha-Tocopherol

Formula: C29H50O2 (430.38106)

CAS ID: 59-02-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

alpha-CEHC

Formula: C16H22O4 (278.1518012)

CAS ID: 4072-32-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

alpha-CMBHC

Formula: C19H28O4 (320.19874880000003)

CAS ID: 7083-09-2

13'-OH-alpha-tocopherol

Formula: C29H50O3 (446.37597500000004)

CAS ID:



Enzyme

EC Number name full name note
1.14.14.1 unspecific monooxygenase substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
1.14.14.78 phylloquinone omega-hydroxylase phylloquinone,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxyphylloquinone forming)
1.14.14.79 docosahexaenoic acid omega-hydroxylase docosahexaenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate forming)
1.14.14.94 leukotriene-B4 20-monooxygenase (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating)


Proteins

Protein ID name full name