heme biosynthesis

Battersby AR, Fookes CJ, Matcham GW, McDonald E. Biosynthesis of the pigments of life: formation of the macrocycle. Nature. 1980 May 01;285(5759):17–21. doi: 10.1038/285017a0. PMID: 6769048.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate

Formula: C14H6ClF3NO5- (359.98865920000003)

CAS ID:



Enzyme

EC Number name full name note
1.3.3.3 coproporphyrinogen oxidase coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
1.3.3.4 protoporphyrinogen oxidase protoporphyrinogen-IX:oxygen oxidoreductase
2.3.1.37 5-aminolevulinate synthase succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
2.5.1.61 hydroxymethylbilane synthase porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
4.1.1.37 uroporphyrinogen decarboxylase uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)
4.2.1.24 porphobilinogen synthase 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
4.2.1.75 uroporphyrinogen-III synthase hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
4.98.1.1 protoporphyrin ferrochelatase protoheme ferro-lyase (protoporphyrin-forming)


Proteins

Protein ID name full name