Lipid A-core biosynthesis

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.58 lipopolysaccharide glucosyltransferase I UDP-glucose:lipopolysaccharide glucosyltransferase
2.4.1.73 lipopolysaccharide glucosyltransferase II UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase
2.4.99.23 lipopolysaccharide heptosyltransferase I ADP-L-glycero-beta-D-manno-heptose:an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid A] 5-alpha-heptosyltransferase
2.4.99.24 lipopolysaccharide heptosyltransferase II ADP-L-glycero-beta-D-manno-heptose:an alpha-L-glycero-D-manno-heptosyl-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] 3-alpha-heptosyltransferase
2.4.99.25 lipopolysaccharide heptosyltransferase III ADP-L-glycero-beta-D-manno-heptose:an alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 7-alpha-heptosyltransferase
2.7.1.235 lipopolysaccharide core heptose(I) kinase ATP:an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 4-O-phosphotransferase


Proteins

Protein ID name full name
P24173 waaC Lipopolysaccharide heptosyltransferase 1
P25740 waaG Lipopolysaccharide glucosyltransferase WaaG
P25741 waaP Lipopolysaccharide core heptose(I) kinase WaaP
P25742 waaQ Lipopolysaccharide heptosyltransferase 3
P27127 waaB Lipopolysaccharide 1,6-galactosyltransferase
P27128 waaO Lipopolysaccharide glucosyltransferase WaaO
P27129 waaJ Lipopolysaccharide 1,2-glucosyltransferase
P27240 waaY Lipopolysaccharide core heptose(II) kinase WaaY
P27242 waaU Putative lipopolysaccharide heptosyltransferase 4
P37692 waaF Lipopolysaccharide heptosyltransferase 2