Isoleucine Biosynthesis

Metabolites

(S)-2-Aceto-2-hydroxybutanoate

Formula: C6H10O4 (146.057906)

CAS ID: 113919-07-6

2-Oxobutanoate

Formula: C4H6O3 (102.0316926)

CAS ID: 600-18-0

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Isoleucine

Formula: C6H13NO2 (131.0946238)

CAS ID: 73-32-5

L-Threonine

Formula: C4H9NO3 (119.0582404)

CAS ID: 72-19-5

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NH4+

Formula: NH4 (18.0343724)

CAS ID: 14798-03-9

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3



Enzyme

EC Number name full name note
4.1.1.-
1.1.1.169 2-dehydropantoate 2-reductase (R)-pantoate:NADP+ 2-oxidoreductase
4.1.1.43 phenylpyruvate decarboxylase phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
4.1.1.72 branched-chain-2-oxoacid decarboxylase (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
4.1.1.74 indolepyruvate decarboxylase 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
4.2.1.9 dihydroxy-acid dehydratase 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming)
4.3.1.16 threo-3-hydroxy-L-aspartate ammonia-lyase threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)


Proteins

Protein ID name full name
P26263 PDC6 Pyruvate decarboxylase isozyme 3
P36007 SRY1 L-threo-3-hydroxyaspartate ammonia-lyase
P38787 PAN5 2-dehydropantoate 2-reductase
P39522 ILV3 Dihydroxy-acid dehydratase, mitochondrial