spermidine biosynthesis I
Li Y, Hess S, Pannell LK, Tabor CW, Tabor H. In vivo mechanism-based inactivation of S -adenosylmethionine decarboxylases from Escherichia coli , Salmonella typhimurium , and Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 2001 Aug 28;98(19):10578–83. doi: 10.1073/pnas.181341198.; Hamasaki-Katagiri N, Tabor CW, Tabor H. Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase). Gene. 1997 Mar 10;187(1):35–43. doi: 10.1016/s0378-1119(96)00660-9. PMID: 9073064.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.5.1.- | |||
| 2.5.1.16 | spermidine synthase | S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase | |
| 2.5.1.22 | spermine synthase | S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase | |
| 2.5.1.79 | thermospermine synthase | S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing) | |
| 4.1.1.50 | adenosylmethionine decarboxylase | S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] |
Proteins
| Protein ID | name | full name |
|---|---|---|
| O34426 | speH | S-adenosylmethionine decarboxylase proenzyme |
| P09158 | speE | Polyamine aminopropyltransferase |
| P0A7F6 | speD | S-adenosylmethionine decarboxylase proenzyme |
| P21182 | SPE2 | S-adenosylmethionine decarboxylase proenzyme |
| Q12074 | SPE3 | Spermidine synthase SPE3 |