Folate Biosynthesis

Metabolites

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

AMP

Formula: C10H14N5O7P (347.06308240000004)

CAS ID: 61-19-8

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

Chorismate

Formula: C10H10O6 (226.04773600000001)

CAS ID: 617-12-9

Dihydropteroate

Formula: C14H14N6O3 (314.1127334)

CAS ID: 2134-76-1

Glycolaldehyde

Formula: C2H4O2 (60.0211284)

CAS ID: 141-46-8

GTP

Formula: C10H16N5O14P3 (522.9906626)

CAS ID: 86-01-1

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.5.1.3 dihydrofolate reductase 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
1.5.1.50 dihydromonapterin reductase 5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase
2.5.1.15 dihydropteroate synthase (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase
2.6.1.85 aminodeoxychorismate synthase chorismate:L-glutamine aminotransferase
2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
3.5.4.16 GTP cyclohydrolase I GTP 7,8-8,9-dihydrolase
3.6.1.67 dihydroneopterin triphosphate diphosphatase 7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase
4.1.2.25 dihydroneopterin aldolase 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
4.1.3.38 aminodeoxychorismate lyase 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
5.1.99.8 7,8-dihydroneopterin epimerase 7,8-dihydroneopterin 2'-epimerase
6.3.2.12 dihydrofolate synthase 7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
6.3.2.17 tetrahydrofolate synthase tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)


Proteins

Protein ID name full name
P00903 pabA Aminodeoxychorismate synthase component 2
P05041 pabB Aminodeoxychorismate synthase component 1
P08192 folC Dihydrofolate synthase/folylpolyglutamate synthase
P0A6T5 folE GTP cyclohydrolase 1
P0ABQ4 folA Dihydrofolate reductase
P0AC13 folP Dihydropteroate synthase
P0AC16 folB Dihydroneopterin aldolase
P0AFC0 nudB Dihydroneopterin triphosphate diphosphatase
P0AFS3 folM Dihydromonapterin reductase
P26281 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P28305 pabC Aminodeoxychorismate lyase