L-isoleucine biosynthesis I (from threonine)

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

2-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.86 ketol-acid reductoisomerase (NADP+) (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2.2.1.6 acetolactate synthase pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
4.2.1.9 dihydroxy-acid dehydratase 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming)
4.3.1.17 L-serine ammonia-lyase L-serine ammonia-lyase (pyruvate-forming)
4.3.1.19 threonine ammonia-lyase L-threonine ammonia-lyase (2-oxobutanoate-forming)


Proteins

Protein ID name full name
O06335 ilvB2 Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS)
O53554 ilvX Probable acetohydroxyacid synthase IlvX (acetolactate synthase)
P9WG39 ilvG Acetolactate synthase large subunit IlvG
P9WG41 ilvB1 Acetolactate synthase large subunit IlvB1
P9WG95 ilvA L-threonine dehydratase biosynthetic IlvA
P9WGT5 sdaA L-serine dehydratase
P9WKJ3 ilvH Putative acetolactate synthase small subunit
P9WKJ5 ilvD Dihydroxy-acid dehydratase
P9WKJ7 ilvC Ketol-acid reductoisomerase (NADP(+))
P9WQ75 ilvE Branched-chain-amino-acid aminotransferase